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Invitrogen
TrkA Recombinant Rabbit Monoclonal Antibody (024)
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FIGURE: 1 / 1
TrkA Antibody (MA5-29456) in IHC (P)
Immunohistochemical staining of human TrkA in human brain with TrkA Recombinant Rabbit Monoclonal Antibody (24) (Product # MA5-29456, 1:200, formalin-fixed paraffin embedded sections). Left panel: tissue incubated with primary antibody. Right panel: tissue incubated with mixture of primary antibody and antigen (recombinant protein).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-29456
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
024
Immunogen
Recombinant Human TrkA/NTRK1 protein (Met1-Pro382)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human TrkA/NTRK1.
Target Information
NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781I14186; EC 2.7.10.1; gp140trk; kinase TrkA; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; trk tyrosine-specific protein kinase; TRK1-transforming tyrosine kinase protein; tropomyosin receptor kinase A; tropomyosin-related kinase A; tyrosine kinase receptor A; unnamed protein product
Gene Aliases: MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA
UniProt ID: (Human) P04629
Entrez Gene ID: (Human) 4914
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
GPI-linked ephrin receptor activity
neurotrophin receptor activity
neurotrophin p75 receptor binding
protein binding
ATP binding
nerve growth factor receptor activity
kinase binding
identical protein binding
protein homodimerization activity
neurotrophin binding
nerve growth factor binding
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
spermatogenesis
axon guidance
learning or memory
circadian rhythm
negative regulation of cell proliferation
response to xenobiotic stimulus
programmed cell death involved in cell development
positive regulation of neuron projection development
peptidyl-tyrosine phosphorylation
olfactory nerve development
neuron projection development
response to nutrient levels
response to nicotine
peptidyl-tyrosine autophosphorylation
nerve growth factor signaling pathway
negative regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
positive regulation of angiogenesis
positive regulation of Ras protein signal transduction
protein autophosphorylation
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
sympathetic nervous system development
neuron development
response to axon injury
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
response to hydrostatic pressure
response to electrical stimulus
positive regulation of protein kinase B signaling
positive regulation of synaptic transmission, glutamatergic
Sertoli cell development
axonogenesis involved in innervation
positive regulation of ERK1 and ERK2 cascade
cellular response to nicotine
cellular response to beta-amyloid
cellular response to nerve growth factor stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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