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Invitrogen
C2 Monoclonal Antibody (06)
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Product Details
MA5-30106
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
06
Immunogen
Recombinant Human Complement Component C2 Protein (Met1-Leu752)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human Complement Component C2.
Target Information
Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C3/C5 convertase; complement component 2; complement component C2; DADB-122G4.1; unnamed protein product
Gene Aliases: ARMD14; CO2
UniProt ID: (Human) P06681
Entrez Gene ID: (Human) 717
complement activation, lectin pathway
activation of membrane attack complex
proteolysis
complement activation
complement activation, classical pathway
response to bacterium
innate immune response
positive regulation of immune response
protein maturation
complement activation, GZMK pathway
positive regulation of opsonization
positive regulation of apoptotic cell clearance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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