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Invitrogen
IGF1 Recombinant Rabbit Monoclonal Antibody (023)
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Product Details
MA5-30511
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
023
Immunogen
Recombinant Human IGF-1/IGF-I/IGF1 protein (Gly49-Ala118)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human IGF1 LR3.
Target Information
IGF1 (Insulin-like growth factor-1) is structurally and functionally related to insulin but has a much higher growth-promoting activity. A variety of cellular responses are induced by IGF1, including cell proliferation, differentiation, migration, and survival. Further, IGF1 is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types in muscle, bone, and cartilage tissue. IGF1 stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regards to enhancing glucose uptake. In circulation, IGFs are predominantly bound to binding proteins (IGFBPs) which prolong the half-life of the IGFs and play a role in delivering them to target tissues. IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of proliferation and an inhibitor of programmed cell death. Moreover, mature human IGF-I is 100% homologous with bovine and porcine proteins. Low levels of IGF1 have been linked to Alzheimer's disease. IGF1 is processed from a precursor, bound by a specific receptor, and secreted. Defects in the IGF1 gene are a cause of insulin-like growth factor 1 deficiency and several transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: H-IGF-1; IGF; IGF-IA; IGF-IB; IGF1; IGF1A; IGFIa; Insulin like growth factor; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor I; insulin-like growth factor I precursor; insulin-like growth factor IB; insulin-like growth factor IB prepropeptide; insulin-like growth factor precursor; M-IGF-1; mechano growth factor; OTTHUMP00000195084; R-IGF-1; Somatomedin C; somatomedin-C; unnamed protein product
Gene Aliases: IGF; IGF-I; IGFI; MGF
UniProt ID: (Human) P05019
Entrez Gene ID: (Human) 3479
skeletal system development
osteoblast differentiation
cell activation
epithelial to mesenchymal transition
signal transduction
Ras protein signal transduction
muscle organ development
circadian rhythm
cell proliferation
positive regulation of cell proliferation
insulin receptor signaling pathway
response to heat
glycolate metabolic process
regulation of gene expression
positive regulation of glycoprotein biosynthetic process
positive regulation of cardiac muscle hypertrophy
positive regulation of gene expression
negative regulation of gene expression
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
muscle hypertrophy
myotube cell development
positive regulation of smooth muscle cell migration
proteoglycan biosynthetic process
positive regulation of cell migration
positive regulation of myelination
activation of protein kinase B activity
negative regulation of interleukin-1 beta production
negative regulation of tumor necrosis factor production
negative regulation of smooth muscle cell apoptotic process
bone mineralization involved in bone maturation
wound healing
positive regulation of activated T cell proliferation
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation of MAPK cascade
positive regulation of skeletal muscle tissue regeneration
positive regulation of insulin-like growth factor receptor signaling pathway
myoblast differentiation
positive regulation of osteoblast differentiation
positive regulation of glycogen biosynthetic process
positive regulation of glycolytic process
positive regulation of mitotic nuclear division
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of glucose import
positive regulation of Ras protein signal transduction
insulin-like growth factor receptor signaling pathway
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of epithelial cell proliferation
positive regulation of protein secretion
protein stabilization
myoblast proliferation
positive regulation of protein kinase B signaling
negative regulation of oocyte development
growth hormone receptor signaling pathway
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of ERK1 and ERK2 cascade
positive regulation of calcineurin-NFAT signaling cascade
negative regulation of release of cytochrome c from mitochondria
receptor signaling pathway via STAT
postsynaptic modulation of chemical synaptic transmission
negative regulation of neuroinflammatory response
negative regulation of beta-amyloid formation
positive regulation of trophectodermal cell proliferation
cellular response to beta-amyloid
positive regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell apoptotic process
positive regulation of transcription regulatory region DNA binding
negative regulation of apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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