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Invitrogen
ACE2 Recombinant Rabbit Monoclonal Antibody (003)
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Product Details
MA5-31273
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
003
Immunogen
Recombinant Rat ACE2/Angiotensin-Converting Enzyme 2 Protein (Met1-Thr740)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Rat ACE2/Angiotensin-Converting Enzyme 2.
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACE 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; dipeptidyl carboxydipeptidases; ACE2; renal angiotensin-converting enzyme 2
UniProt ID: (Rat) Q5EGZ1
Entrez Gene ID: (Rat) 302668
negative regulation of transcription from RNA polymerase II promoter
angiotensin maturation
angiotensin-mediated drinking behavior
regulation of systemic arterial blood pressure by renin-angiotensin
proteolysis
tryptophan transport
viral entry into host cell
receptor-mediated virion attachment to host cell
negative regulation of smooth muscle cell proliferation
regulation of inflammatory response
positive regulation of amino acid transport
maternal process involved in female pregnancy
positive regulation of cardiac muscle contraction
negative regulation of ERK1 and ERK2 cascade
amino acid import across plasma membrane
entry receptor-mediated virion attachment to host cell
positive regulation of gap junction assembly
regulation of cardiac conduction
positive regulation of L-proline import across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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