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Invitrogen
VAV1 Monoclonal Antibody (GT557)
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FIGURE: 1 / 4
VAV1 Antibody (MA5-31488) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of VAV1 was performed in Jurkat cells fixed in 4% paraformaldehyde at RT for 15 min. Green: VAV1 Monoclonal Antibody (GT557) (Product # MA5-31488) diluted at 1:500. Blue: Fluoroshield with DAPI. Scale bar = 10 µm.
Product Details
MA5-31488
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
GT557
Immunogen
Recombinant protein encompassing a sequence within the center region of human VAV1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (92%), Rat (92%), Pig (96%), Bovine (96%).
Positive Control: Jurkat, NCI-H929.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The VAV1 gene, located on chromosome 19p13.2, encodes for a protein that functions as a guanine nucleotide exchange factor (GEF). Structurally, the VAV1 protein contains several functional domains, including Dbl homology (DH) and pleckstrin homology (PH) domains, which facilitate its role in exchange activity, and SH3 and SH2 domains, critical for signal transduction. VAV1 is primarily expressed in hematopoietic cells and plays a crucial role in the regulation of immune responses, particularly in T-cell receptor signaling. It influences actin cytoskeleton reorganization, cell proliferation, and differentiation, making it vital for proper immune system function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: oncogene vav; p95vav; Proto-oncogene vav; unnamed protein product; vav 1 guanine nucleotide exchange factor; vav 1 oncogene; vav oncogene; vav proto-oncogene
Gene Aliases: VAV; vav-T; VAV1
UniProt ID: (Human) P15498, (Mouse) P27870
Entrez Gene ID: (Human) 7409, (Mouse) 22324
phagocytosis
immune response
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
small GTPase mediated signal transduction
T cell differentiation
neutrophil chemotaxis
regulation of Rho protein signal transduction
intracellular signal transduction
T cell activation
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of natural killer cell mediated cytotoxicity
reactive oxygen species metabolic process
immune response-regulating cell surface receptor signaling pathway
regulation of cell size
response to xenobiotic stimulus
cell migration
natural killer cell activation
platelet activation
T cell costimulation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
B cell proliferation
natural killer cell mediated cytotoxicity
vascular endothelial growth factor receptor signaling pathway
regulation of small GTPase mediated signal transduction
positive regulation of protein kinase B signaling
cellular response to xenobiotic stimulus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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