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Invitrogen
PRMT1 Monoclonal Antibody (GT10111)
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FIGURE: 1 / 5
PRMT1 Antibody (MA5-31503) in IHC (P)
Immunohistochemistry (Paraffin) analysis of PRMT1 was performed in paraffin-embedded human cervical carcinoma tissue using PRMT1 Monoclonal Antibody (GT10111) (Product # MA5-31503) at a dilution of 1:200. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-31503
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
GT10111
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PRMT1. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%), Bovine (100%).
Positive Control: 293T, A431, HeLa, HepG2, Neuro2A, GL261, NIH-3T3, Raw264.7, C2C12.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PRMT1 is a member of the protein arginine N-methyltransferase (PRMT) family. Arginine methylation is an irreversible post translational modification which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Increased expression of PRMT1 may play a role in various types of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: arginine N-methyltransferase 1; heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; heterogeneous nuclear ribonucleoproteins methyltransferase-like 2; highly conserved protein 1; histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HRMT1L2; interferon receptor 1-bound protein 4; Mrmt1; protein arginine N-methyltransferase 1 isoform 10; protein arginine N-methyltransferase 1 isoform 11; protein arginine N-methyltransferase 1 isoform 12; protein arginine N-methyltransferase 1 isoform 13; protein arginine N-methyltransferase 1 isoform 14; protein arginine N-methyltransferase 1 isoform 15; protein arginine N-methyltransferase 1 isoform 16; protein arginine N-methyltransferase 1 isoform 17; protein arginine N-methyltransferase 1 isoform 18; protein arginine N-methyltransferase 1 isoform 19; protein arginine N-methyltransferase 1 isoform 20; protein arginine N-methyltransferase 1 isoform 21; protein arginine N-methyltransferase 1 isoform 22; protein arginine N-methyltransferase 1 isoform 23; protein arginine N-methyltransferase 1 isoform 24; protein arginine N-methyltransferase 1 isoform 25; protein arginine N-methyltransferase 1 isoform 26; protein arginine N-methyltransferase 1 isoform 27; protein arginine N-methyltransferase 1 isoform 28; protein arginine N-methyltransferase 1 isoform 29; protein arginine N-methyltransferase 1 isoform 30; protein arginine N-methyltransferase 1 isoform 31; protein arginine N-methyltransferase 1 isoform 32; protein arginine N-methyltransferase 1 isoform 33; protein arginine N-methyltransferase 1 isoform 34; protein arginine N-methyltransferase 1 isoform 35; protein arginine N-methyltransferase 1 isoform 36; protein arginine N-methyltransferase 1 isoform 37; protein arginine N-methyltransferase 1 isoform 38; protein arginine N-methyltransferase 1 isoform 39; protein arginine N-methyltransferase 1 isoform 4; protein arginine N-methyltransferase 1 isoform 40; protein arginine N-methyltransferase 1 isoform 41; protein arginine N-methyltransferase 1 isoform 42; protein arginine N-methyltransferase 1 isoform 43; protein arginine N-methyltransferase 1 isoform 44; protein arginine N-methyltransferase 1 isoform 45; protein arginine N-methyltransferase 1 isoform 46; protein arginine N-methyltransferase 1 isoform 47; protein arginine N-methyltransferase 1 isoform 48; protein arginine N-methyltransferase 1 isoform 5; protein arginine N-methyltransferase 1 isoform 6; protein arginine N-methyltransferase 1 isoform 7; protein arginine N-methyltransferase 1 isoform 8; protein arginine N-methyltransferase 1 isoform 9; unnamed protein product
Gene Aliases: 6720434D09Rik; ANM1; HCP1; HRMT1L2; IR1B4; Mrmt1
UniProt ID: (Human) Q99873, (Mouse) Q9JIF0
Entrez Gene ID: (Human) 3276, (Mouse) 15469
RNA binding
protein binding
methyltransferase activity
N-methyltransferase activity
protein methyltransferase activity
methyl-CpG binding
arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
enzyme binding
protein-arginine omega-N monomethyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
identical protein binding
histone methyltransferase activity (H4-R3 specific)
mitogen-activated protein kinase p38 binding
GATOR1 complex binding
histone H4 methyltransferase activity
S-adenosyl-L-methionine binding
snoRNP binding
double-strand break repair via homologous recombination
in utero embryonic development
chromatin remodeling
regulation of transcription, DNA-templated
protein methylation
cellular response to DNA damage stimulus
positive regulation of cell proliferation
RNA splicing
negative regulation of translation
peptidyl-arginine methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
BMP signaling pathway
regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
neuron projection development
cellular response to nutrient levels
cellular response to amino acid starvation
peptidyl-arginine omega-N-methylation
TORC1 signaling
negative regulation of apoptotic process
positive regulation of erythrocyte differentiation
regulation of megakaryocyte differentiation
negative regulation of megakaryocyte differentiation
positive regulation of translation
negative regulation of translational initiation
negative regulation of JNK cascade
cardiac muscle tissue development
protein homooligomerization
cellular response to methionine
protein localization to lysosome
membraneless organelle assembly
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
positive regulation of double-strand break repair via homologous recombination
negative regulation of double-strand break repair via homologous recombination
cell surface receptor signaling pathway
viral protein processing
positive regulation of hemoglobin biosynthetic process
positive regulation of p38MAPK cascade
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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