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Invitrogen
TDG Monoclonal Antibody (GT311)
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Product Details
MA5-31521
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
GT311
Immunogen
Recombinant protein encompassing a sequence within the center region of human TDG. The exact sequence is proprietary.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 20% glycerol
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (99%), Xenopus laevis (92%), Chicken (95%), Bovine (99%).
Positive Control: human TDG -transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mis paired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-JUN leucine zipper interactive protein JZA-3; G/T mismatch-specific thymine DNA glycosylase; hTDG; Thymine-DNA glycosylase; unnamed protein product
Gene Aliases: E130317C12Rik; hTDG; JZA-3; Jza1; TDG
UniProt ID: (Human) Q13569, (Mouse) P56581
Entrez Gene ID: (Human) 6996, (Mouse) 21665
magnesium ion binding
mismatch base pair DNA N-glycosylase activity
nucleic acid binding
DNA binding
damaged DNA binding
double-stranded DNA binding
transcription cofactor activity
uracil DNA N-glycosylase activity
protein kinase C binding
protein binding
ATP binding
pyrimidine-specific mismatch base pair DNA N-glycosylase activity
hydrolase activity
DNA N-glycosylase activity
protein domain specific binding
mismatched DNA binding
sodium ion binding
chloride ion binding
SUMO binding
G/U mismatch-specific uracil-DNA glycosylase activity
DNA-binding transcription factor binding
G/T mismatch-specific thymine-DNA glycosylase activity
RNA polymerase II transcription cofactor activity
transcription factor binding
hydrolase activity, acting on glycosyl bonds
hydrolase activity, hydrolyzing N-glycosyl compounds
protein homodimerization activity
structure-specific DNA binding
DNA metabolism protein
DNA glycosylase
nucleic acid metabolism protein
negative regulation of transcription from RNA polymerase II promoter
DNA repair
base-excision repair
base-excision repair, AP site formation
chromatin organization
cellular response to DNA damage stimulus
regulation of gene expression, epigenetic
depyrimidination
regulation of embryonic development
chromosomal 5-methylcytosine DNA demethylation, oxidation pathway
mismatch repair
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
metabolic process
embryo development
chromatin modification
negative regulation of protein binding
negative regulation of chromatin binding
DNA demethylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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