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Invitrogen
PAX3 Monoclonal Antibody (GT2411)
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FIGURE: 1 / 4
PAX3 Antibody (MA5-31582) in WB
Western blot was performed using Anti-PAX3 Monoclonal Antibody, (Product # MA5-31582) and a ~52 kDa band corresponding to PAX3 was observed across the panel tested except T-47D and MCF-7 which are reported to be negative. An uncharacterized band (*) at ~110kDa was also observed across the panel tested. Modified Whole cell extracts (1% SDS) (30 µg lysate) of A-375 (Lane 1), U-87 MG (Lane 2), HEK-293 (Lane 3), T-47D (Lane 4), MCF-7 (Lane 5), Neuro-2a (Lane 6), PC-12 (Lane 7) and NIH/3T3 (Lane 8) were electrophoresed using Novex® NuPAGE® 4-12... View More
Product Details
MA5-31582
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
GT2411
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human PAX3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Positive Control: U87-MG, U87-MG nuclear extract.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Pax 3 (Paired Box 3) is a transcription factor that is involved in development of the peripheral nervous system, melanocytes, some vascular smooth muscle, and a number of other derivatives. It regulates neurogenesis in pre-migratory neural crest cells from the dorsal neural tube, and in myogenic progenitors in the presomitic mesoderm and the hypaxial somites. Alternative splicing results in isoforms having different C-termini.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: homeodomain protein PAX3; HuP2; MGC120381; MGC120382; MGC120383; MGC120384; MGC134778; paired box gene 3; paired box homeotic gene 3; Paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; PAX-3; PAX3/FKHR fusion; transcription factor; transcriptional factor PAX3; unnamed protein product
Gene Aliases: CDHS; HUP2; PAX-3; PAX3; Sp; splotch; WS1; WS3
UniProt ID: (Human) P23760, (Mouse) P24610
Entrez Gene ID: (Human) 5077, (Rat) 114502, (Mouse) 18505
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
chromatin binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
HMG box domain binding
homeodomain transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
nervous system development
muscle organ development
sensory perception of sound
anatomical structure morphogenesis
organ morphogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
neural tube closure
transcription from RNA polymerase II promoter
heart development
cell proliferation
positive regulation of cell proliferation
regulation of somitogenesis
cell migration
spinal cord association neuron differentiation
neural tube development
gliogenesis
developmental pigmentation
neuron fate commitment
skeletal muscle organ development
mammary gland specification
transcription, DNA-templated
multicellular organism development
skeletal muscle cell differentiation
cardiac muscle cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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