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Invitrogen
GLRA1 Monoclonal Antibody (7F8E2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-31740
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
7F8E2
Immunogen
Purified recombinant fragment of human GLRA1 (AA: extra 29-154) expressed in E. coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-31740 has been tested in indirect ELISA.
Target Information
GLRA1 is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in GLRA1 are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found for GLRA1. Glycine receptors (GlyR) that include GLRA1 are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. GLRA1 are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem. Diseases associated with GLRA1 include Hyperekplexia, Hereditary 1 and Hyperekplexia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GLRA; Glra2; glycine receptor; glycine receptor 48 kDa subunit; glycine receptor strychnine-binding subunit; gra1; unnamed protein product
Gene Aliases: HKPX1; STHE
UniProt ID: (Human) P23415
Entrez Gene ID: (Human) 2741
transmembrane signaling receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
protein binding
zinc ion binding
glycine binding
extracellular-glycine-gated chloride channel activity
transmitter-gated ion channel activity
taurine binding
identical protein binding
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
startle response
ion transport
chloride transport
muscle contraction
neuropeptide signaling pathway
ion transmembrane transport
regulation of membrane potential
negative regulation of transmission of nerve impulse
synaptic transmission, glycinergic
excitatory postsynaptic potential
inhibitory postsynaptic potential
cellular response to amino acid stimulus
cellular response to zinc ion
cellular response to ethanol
response to alcohol
regulation of presynaptic membrane potential
chloride transmembrane transport
positive regulation of acrosome reaction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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