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Invitrogen
mGluR3 Monoclonal Antibody (7A5A6)
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FIGURE: 1 / 6
mGluR3 Antibody (MA5-31750) in ICC/IF
Immunocytochemistry analysis of mGluR3 in Hela cells (green). Sample was incubated with mGluR3 monoclonal antibody (Product # MA5-31750) using a dilution of 1:200-1:1000 followed by DRAQ5 fluorescent DNA dye (blue), and Alexa Fluor- 555 phalloidin (red labeled actin filaments) .
Product Details
MA5-31750
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
7A5A6
Immunogen
Purified recombinant fragment of human GRM3 (AA: extra 433-576) expressed in E. coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-31750 has been tested in indirect ELISA.
Target Information
Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include mGluR1a and mGluR5. The Group-II receptors in include mGluR2 and mGluR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glutamate receptor; glutamate receptor, metabotropic 3; M mGlu3; Metabotropic glutamate receptor 3; mGluR3; unnamed protein product
Gene Aliases: GLUR3; GPRC1C; GRM3; mGlu3; MGLUR3
UniProt ID: (Human) Q14832
Entrez Gene ID: (Human) 2913
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
chemical synaptic transmission
gene expression
cellular response to stress
modulation of synaptic transmission
regulation of synaptic transmission, glutamatergic
postsynaptic modulation of chemical synaptic transmission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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