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Invitrogen
KPNA2 Monoclonal Antibody (1E8B7)
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FIGURE: 1 / 8
KPNA2 Antibody (MA5-31790) in ICC/IF
Immunocytochemistry analysis of KPNA2 in Hela cells (green). Sample was incubated with KPNA2 monoclonal antibody (Product # MA5-31790) using a dilution of 1:200-1:1000 followed by DRAQ5 fluorescent DNA dye (blue), and Alexa Fluor- 555 phalloidin (red labeled actin filaments) .
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-31790
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E8B7
Immunogen
Purified recombinant fragment of human KPNA2 (AA: 1-530) expressed in E. coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-31790 has been tested in indirect ELISA.
Target Information
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1, which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in VJ recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMA2; importin alpha 1; importin alpha 2; importin alpha P1; importin subunit alpha-2; importin-alpha-P1; IPOA 1; IPOA1 QIP2; karyopherin (importin) alpha 2; Karyopherin A2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); m-importin-alpha-P1; nuclear pore-targeting complex 58kD component; pendulin; pore targeting complex 58 kDa subunit; RAG cohort 1; RAG cohort protein 1; RCH 1; SRP 1; SRP1 alpha; SRP1-alpha; unnamed protein product
Gene Aliases: 2410044B12Rik; IPOA1; PTAC58; QIP2; RCH1; SRP1-alpha; SRP1alpha
UniProt ID: (Human) P52292, (Mouse) P52293
Entrez Gene ID: (Human) 3838, (Mouse) 16647
protein import into nucleus
NLS-bearing protein import into nucleus
positive regulation of type I interferon production
NIK/NF-kappaB signaling
positive regulation of transcription, DNA-templated
regulation of transcription by glucose
entry of viral genome into host nucleus through nuclear pore complex via importin
postsynapse to nucleus signaling pathway
positive regulation of viral life cycle
regulation of DNA recombination
DNA metabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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