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Invitrogen
PKHD1 Monoclonal Antibody (8G12A1)
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FIGURE: 1 / 5
PKHD1 Antibody (MA5-31848) in ICC/IF
Immunocytochemistry analysis of PKHD1 in A431 cells (green). Sample was incubated with PKHD1 monoclonal antibody (Product # MA5-31848) using a dilution of 1:200-1:1000 followed by DRAQ5 fluorescent DNA dye (blue), and Alexa Fluor- 555 phalloidin (red labeled actin filaments) .
Product Details
MA5-31848
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
8G12A1
Immunogen
Purified recombinant fragment of mouse PKHD1 (AA: 3878-4060) expressed in E. coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-31848 has been tested in indirect ELISA.
Target Information
The protein encoded by this gene is predicted to have a single transmembrane (TM)-spanning domain and multiple copies of an immunoglobulin-like plexin-transcription-factor domain. Alternative splicing results in two transcript variants encoding different isoforms. Other alternatively spliced transcripts have been described, but the full length sequences have not been determined. Several of these transcripts are predicted to encode truncated products which lack the TM and may be secreted. Mutations in this gene cause autosomal recessive polycystic kidney disease, also known as polycystic kidney and hepatic disease-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI118496; AI182499; Fibrocystin; fibrocystin/polyductin complex; PKHD1, fibrocystin/polyductin; polycystic kidney and hepatic disease 1 (autosomal recessive); Polycystic kidney and hepatic disease 1 protein; Polyductin; TIG multiple domains 1; Tigmin; unnamed protein product
Gene Aliases: AI118496; AI182499; ARPKD; FCYT; FPC; PCYT; PKD4; PKHD1; TIGM1
UniProt ID: (Human) P08F94, (Mouse) E9PZ36
Entrez Gene ID: (Human) 5314, (Mouse) 241035
establishment of mitotic spindle orientation
kidney development
regulation of cell-matrix adhesion
epithelial cell morphogenesis
cellular calcium ion homeostasis
positive regulation of cell proliferation
regulation of centrosome duplication
regulation of cell-cell adhesion
regulation of cell adhesion
regulation of TOR signaling
negative regulation of NF-kappaB transcription factor activity
homeostatic process
negative regulation of apoptotic process
cell-cell junction organization
branching morphogenesis of an epithelial tube
positive regulation of epithelial cell proliferation
establishment of centrosome localization
negative regulation of protein kinase B signaling
cilium morphogenesis
regulation of ERK1 and ERK2 cascade
regulation of establishment of planar polarity
cell-cell adhesion
negative regulation of epithelial cell apoptotic process
regulation of cholangiocyte proliferation
cilium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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