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Invitrogen

Phospho-TrkB (Tyr817) Recombinant Rabbit Monoclonal Antibody (SC0556)

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Phospho-TrkB (Tyr817) Recombinant Rabbit Monoclonal Antibody (SC0556)

Product Details

MA5-32207

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SC0556

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Tyr817 of Human TrkB aa 789-822.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.02 mg/mL

Amount

102 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809494

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AI848316; BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP145TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; NTRK2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; Trk B; Trk-B; TrkB; TrkB tyrosine kinase; TrkB-T-Shc; Tropomyosin-related kinase B; truncated trkB; tyrosine kinase receptor B; unnamed protein product

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Gene Aliases: DEE58; EIEE58; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2; OBHD; RATTRKB1; Tkrb; trk-B; TRKB; TRKB1

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UniProt ID: (Human) Q16620, (Mouse) P15209, (Rat) Q63604

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Entrez Gene ID: (Human) 4915, (Mouse) 18212, (Rat) 25054

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Function(s)
nucleotide binding protease binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity neurotrophin receptor activity protein binding ATP binding kinase activity transferase activity protein homodimerization activity neurotrophin binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding transmembrane signal receptor
Process(es)
vasculogenesis neuron migration transmembrane receptor protein tyrosine kinase signaling pathway nervous system development learning circadian rhythm feeding behavior positive regulation of cell proliferation positive regulation of gene expression positive regulation of neuron projection development glutamate secretion regulation of metabolic process neuronal action potential propagation central nervous system neuron development cerebral cortex development myelination in peripheral nervous system cell differentiation neuron differentiation brain-derived neurotrophic factor receptor signaling pathway neurotrophin signaling pathway mechanoreceptor differentiation regulation of GTPase activity positive regulation of MAPK cascade negative regulation of neuron apoptotic process retinal rod cell development protein autophosphorylation oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of protein kinase B signaling positive regulation of protein kinase B signaling positive regulation of synapse assembly retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus trans-synaptic signaling by BDNF, modulating synaptic transmission negative regulation of beta-amyloid formation cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis protein phosphorylation multicellular organism development neuromuscular junction development long-term memory positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation peptidyl-tyrosine phosphorylation positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source regulation of MAPK cascade regulation of neurotransmitter secretion regulation of dendrite development positive regulation of synaptic transmission, glutamatergic positive regulation of glucocorticoid receptor signaling pathway inflammatory response aging response to light stimulus response to auditory stimulus cellular response to tumor necrosis factor cellular response to nerve growth factor stimulus
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