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Invitrogen

HLA-DR Recombinant Rabbit Monoclonal Antibody (SC06-78)

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HLA-DR Recombinant Rabbit Monoclonal Antibody (SC06-78)

Product Details

MA5-32232

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SC06-78

Immunogen

Synthetic peptide within Human HLA-DRA aa 159-195 (Extracellular).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.07 mg/mL

Amount

107 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809518

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; class II MHC-associated invariant chain peptide; class II-associated invariant chain peptide; DASS-397D15.1; dinucleotide microsatellite; DR beta-5; DR7 beta-chain glycoprotein; DRB1; DRB52; DRw53 beta-chain glycoprotein; ERLA-005; FLJ51114; FLJ75017; FLJ76359; gamma chain of class II antigens; H-2 class II histocompatibility antigen, E-D alpha chain; H-2 class II histocompatibility antigen, E-K alpha chain; H-2 class II histocompatibility antigen, E-U alpha chain; H2-Ea; H2-IE-alpha; histocompatibility 2, class II antigen E alpha, pseudogene; histocompatibility antigen HLA-DR alpha; histocompatibility: class II antigens, gamma chain of; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA-DR alpha-chain; hla-dr antigen alpha chain; hla-dr antigen heavy chain; HLA-DR antigens-associated invariant chain; HLA-DR-alpha chain precursor; HLA-DR-beta chain; HLA-DR-GAMMA; HLA-DR11-14N allele; HLA-DRA; HLA-DRB1; human leucocyte antigen; human leucocyte antigen DRB1; human leucocyte antigen DRB3; I-E alpha MHC class II; ia antigen-associated invariant chain; Ia-associated invariant chain; ii; ii chain; invariant polypeptide of major histocompatibility complex, class II antigen-associated; leukocyte antigen; lymphocyte antigen DRB1; major histocompatibility complex, class II, DRB3; MHC class II alpha chain; MHC class II antigen; MHC class II antigen DR beta 3 chain; MHC class II antigen DRA; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen E alpha; MHC class II antigen IEk-alpha; MHC class II DR beta chain; MHC class II H2-E alpha chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR4 protein; MHC class II HLA-DR4/w53 protein; MHC class II protein; MHC class II-associated invariant chain; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-1 chain; MHC DR7-beta-2 chain; MHC H2-IE-alpha cell surface glycoprotein; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-DR gamma chain; MHC HLA-DR-beta chain; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta surface glycoprotein; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-1 precursor; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)a glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)a glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DR2(non-Dw2/non-Dw12)a glycoprotein beta-chain; MHC HLA-DRw10-beta-2 protein precursor; unnamed protein product; XXbac-BPG161M6.1

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Gene Aliases: CLIP; DHLAG; DR4; DRB1; DRB3; DRB4; DRB5; E-alpha-f; H-2Ea; H2-Ea-ps; HLA DRB3; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRA1; HLA-DRB; HLA-DRB3*; HLA-DRB4*; HLA-DRB5*; HLADG; I-Ealpha; Ia-3; Ia-GAMMA; Ia3; II; INVG34; MHC-H2-Ea; p33; SS1

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UniProt ID: (Human) P04233, (Rat) P10247, (Mouse) P04441, (Mouse) P04224, (Human) P01903, (Human) P01911, (Human) P79483, (Human) P13762, (Human) Q30154

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Entrez Gene ID: (Human) 972, (Rat) 25599, (Mouse) 16149, (Mouse) 100504404, (Human) 3122, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127

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Function(s)
beta-amyloid binding cytokine receptor activity protein binding cytokine binding MHC class II protein complex binding macrophage migration inhibitory factor binding MHC class II protein binding CD4 receptor binding MHC class II protein binding, via antigen binding groove identical protein binding protein binding involved in protein folding nitric-oxide synthase binding peptide antigen binding polysaccharide binding T cell receptor binding structural constituent of cytoskeleton MHC class II receptor activity
Process(es)
peptide antigen assembly with MHC class II protein complex immune response antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of immune response positive regulation of T cell activation positive regulation of T cell mediated cytotoxicity myeloid dendritic cell antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class II antigen processing and presentation of peptide or polysaccharide antigen via MHC class II positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of memory T cell differentiation regulation of T-helper cell differentiation cognition positive regulation of CD4-positive, alpha-beta T cell activation prostaglandin biosynthetic process positive regulation of cytokine-mediated signaling pathway T cell activation involved in immune response positive regulation of dendritic cell antigen processing and presentation negative regulation of peptide secretion positive regulation of type 2 immune response negative regulation of mature B cell apoptotic process protein folding intracellular protein transport positive regulation of gene expression immunoglobulin mediated immune response antigen processing and presentation of endogenous antigen negative regulation of cell migration positive regulation of B cell proliferation positive regulation of prostaglandin biosynthetic process positive regulation of chemokine production positive regulation of interleukin-6 production positive regulation of interleukin-8 production response to interferon-gamma macrophage migration inhibitory factor signaling pathway regulation of macrophage activation negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade negative regulation of DNA damage response, signal transduction by p53 class mediator T cell selection positive regulation of monocyte differentiation negative regulation of viral entry into host cell positive regulation of fibroblast proliferation protein stabilization positive regulation of macrophage cytokine production protein-containing complex assembly protein trimerization positive regulation of ERK1 and ERK2 cascade positive regulation of neutrophil chemotaxis negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of macrophage migration inhibitory factor signaling pathway positive regulation of T cell mediated immune response to tumor cell signal transduction T cell receptor signaling pathway defense response I-kappaB kinase/NF-kappaB signaling signal transduction involved in regulation of gene expression positive thymic T cell selection negative thymic T cell selection negative regulation of T cell differentiation positive regulation of T cell differentiation positive regulation of inflammatory response positive regulation of cytokine production involved in inflammatory response positive regulation of NIK/NF-kappaB signaling positive regulation of adaptive immune response positive regulation of innate immune response positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell immune system process inflammatory response to antigenic stimulus negative regulation of inflammatory response to antigenic stimulus humoral immune response cytoskeleton organization epidermis development detection of bacterium macrophage differentiation regulation of interleukin-10 production regulation of interleukin-4 production negative regulation of interferon-gamma production positive regulation of insulin secretion involved in cellular response to glucose stimulus T-helper 1 type immune response negative regulation of T cell proliferation protein tetramerization
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