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Invitrogen

TCF7L2 Recombinant Rabbit Monoclonal Antibody (SC06-90)

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TCF7L2 Recombinant Rabbit Monoclonal Antibody (SC06-90)

Product Details

MA5-32240

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

1:50-1:100
-

ChIP assay (ChIP)

2.5 µg/10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SC06-90

Immunogen

Synthetic peptide within Human TCF7L2 aa 1-49.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809526

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9L, 10, 11, 12, 13, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9L, 10, 11, 12, 15, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9L, 10, 11, 12, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9S, 10, 11, 12, 13, 14, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9S, 10, 11, 12, 13, 17; contains exons 1, 2, 3, 4, 5, 6, 7L, 8, 9S, 10, 11, 12, 17; contains exons 1, 2, 3, 4, 5, 6, 7S, 8, 9S, 10, 11, 12, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9L, 10, 11, 12, 15, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9L, 10, 11, 12, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9S, 10, 11, 12, 13, 14, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9S, 10, 11, 12, 15, 17; contains exons 1, 2, 3, 5, 6, 7L, 8, 9S, 10, 11, 12, 17; contains exons 1, 2, 3, 5, 6, 7S, 8, 9S, 10, 11, 12, 17; contains exons 8, 9L, 10, 11, 12, 13, 14, 17; HMG box transcription factor 4; hTCF; hTCF 4; hTCF-4; mTCF-4; RP11-357H24.1; T-cell factor 4; T-cell-specific transcription factor 4; TCF 4; TCF7L2; TCF7L2 protein; transcription factor; Transcription factor 7-like 2; transcription factor 7-like 2 (T-cell specific, HMG-box); transcription factor 7-like 2, T-cell specific, HMG-box; unnamed protein product

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Gene Aliases: mTcf-4B; mTcf-4E; TCF-4; TCF4; TCF4B; TCF4E; TCF7L2

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UniProt ID: (Human) Q9NQB0, (Mouse) Q924A0

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Entrez Gene ID: (Human) 6934, (Rat) 679869, (Mouse) 21416

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding ligand-dependent nuclear receptor binding protein kinase binding sequence-specific DNA binding gamma-catenin binding RNA polymerase II sequence-specific DNA binding transcription factor binding armadillo repeat domain binding promoter-specific chromatin binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II repressing transcription factor binding molecular_function chromatin binding transcription factor binding nuclear hormone receptor binding transcription regulatory region DNA binding DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter blood vessel development regulation of transcription from RNA polymerase II promoter response to glucose positive regulation of epithelial to mesenchymal transition positive regulation of heparan sulfate proteoglycan biosynthetic process Wnt signaling pathway pancreas development positive regulation of insulin secretion regulation of hormone metabolic process glucose homeostasis maintenance of DNA repeat elements fat cell differentiation negative regulation of gluconeogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter myoblast fate commitment regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation positive regulation of protein kinase B signaling canonical Wnt signaling pathway negative regulation of androgen receptor signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of protein localization to nucleus negative regulation of type B pancreatic cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway cellular glucose homeostasis glycogen metabolic process glucose metabolic process regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cell cycle arrest biological_process cell proliferation cellular response to starvation post-embryonic development positive regulation of triglyceride biosynthetic process oligodendrocyte development neural tube development pituitary gland development bone mineralization negative regulation of BMP signaling pathway embryonic genitalia morphogenesis regulation of myelination positive regulation of protein binding secretory granule localization somatic stem cell population maintenance multicellular organism growth catenin import into nucleus regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter negative regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth positive regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity skin development canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of transcription, DNA-templated negative regulation of organ growth positive regulation of protein export from nucleus positive regulation of lipid biosynthetic process embryonic digestive tract morphogenesis embryonic hindgut morphogenesis regulation of skeletal muscle tissue development regulation of oligodendrocyte differentiation face morphogenesis regulation of insulin secretion involved in cellular response to glucose stimulus insulin metabolic process transcription, DNA-templated generation of neurons
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