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Invitrogen
Dystrophin Recombinant Rabbit Monoclonal Antibody (JF1-022)
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Product Details
MA5-32565
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JF1-022
Immunogen
Synthetic peptide within Human Dystrophin aa 3651-3685.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Dystrophin is the 427kDa protein product of the DMB/BMD gene located on the X chromosome at position Xp21. Western blotting and immunohistochemistry are the two established methods for the detection of abnormalities of dystrophin expression in muscle biopsies. Dystrophin abnormalities are thought to occur in 100% of patients with DMD/BMD, although genetic abnormalities may only be detected in up to 65% of cases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apodystrophin-3; apodystrophin-I; DMD; Dpm234; Duchenne muscular dystrophy (DMD); Dystrophin; dystrophin Dp40; dystrophin Dp71a; dystrophin Dp71ab; dystrophin Dp71b; dystrophin, muscular dystrophy; GS1-19O24.1; Muscular dystrophy Duchenne and Becker types; mutant dystrophin; OTTHUMP00000215592; unnamed protein product; X-linked muscular dystrophy
Gene Aliases: BMD; CMD3B; DMD; DNADMD1; Dp427; Dp71; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272; DXSmh7; DXSmh9; dys; mdx; MRX85; pke
UniProt ID: (Human) P11532, (Mouse) P11531, (Rat) P11530
Entrez Gene ID: (Human) 1756, (Mouse) 13405, (Rat) 24907
dystroglycan binding
actin binding
structural constituent of cytoskeleton
protein binding
zinc ion binding
structural constituent of muscle
myosin binding
vinculin binding
metal ion binding
nitric-oxide synthase binding
integrin binding
PDZ domain binding
protein complex binding
ubiquitin-protein ligase
regulation of heart rate
muscle contraction
cytoskeleton organization
muscle organ development
skeletal muscle tissue development
protein localization
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
positive regulation of neuron projection development
regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
regulation of skeletal muscle contraction
maintenance of blood-brain barrier
response to muscle stretch
peptide biosynthetic process
regulation of system process
motile cilium assembly
positive regulation of neuron differentiation
muscle cell cellular homeostasis
neuron development
muscle cell development
cardiac muscle contraction
protein-containing complex assembly
cardiac muscle cell action potential
regulation of muscle system process
regulation of cellular response to growth factor stimulus
synaptic signaling
regulation of sodium ion transmembrane transport
regulation of calcium ion transmembrane transport
positive regulation of cell-matrix adhesion
regulation of transcription, DNA-templated
establishment of blood-nerve barrier
regulation of gene expression
myotube cell development
muscle attachment
olfactory nerve structural organization
negative regulation of peptidyl-serine phosphorylation
cellular protein localization
regulation of membrane potential
cellular protein complex assembly
neurotransmitter receptor metabolic process
muscle fiber development
nucleus localization
regulation of ryanodine-sensitive calcium-release channel activity
establishment of glial blood-brain barrier
negative regulation of ERK1 and ERK2 cascade
regulation of voltage-gated calcium channel activity
negative regulation of peptidyl-cysteine S-nitrosylation
positive regulation of sodium ion transmembrane transporter activity
aging
cell differentiation
muscle cell differentiation
neuron projection morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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