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Invitrogen
MAD2L2 Recombinant Rabbit Monoclonal Antibody (JU99-23)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-32822
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JU99-23
Immunogen
Synthetic peptide within Human Mad2L2 aa 162-211.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hREV7; MAD2 (mitotic arrest deficient, yeast, homolog)-like 2; MAD2 mitotic arrest deficient-like 2; MAD2-like protein 2; mitotic arrest deficient 2-like protein 2; mitotic arrest deficient homolog-like 2; polymerase (DNA-directed), zeta 2, accessory subunit; REV7 homolog; RP3-330O12.4; similar to mitotic checkpoint protein hMAD2; spindle-assembly checkpoint protein homolog; unnamed protein product
Gene Aliases: 2310033C13Rik; FANCV; G1-453-4; MAD2B; POLZ2; repro22; REV7
UniProt ID: (Human) Q9UI95, (Mouse) Q9D752, (Rat) D3Z8D9
Entrez Gene ID: (Human) 10459, (Mouse) 71890, (Rat) 313702
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
somatic diversification of immunoglobulins involved in immune response
DNA repair
double-strand break repair
actin filament organization
positive regulation of gene expression
regulation of epithelial to mesenchymal transition
positive regulation of epithelial to mesenchymal transition
negative regulation of epithelial to mesenchymal transition
translesion synthesis
positive regulation of peptidyl-serine phosphorylation
negative regulation of protein catabolic process
error-prone translesion synthesis
DNA damage response, signal transduction resulting in transcription
telomere maintenance in response to DNA damage
positive regulation of isotype switching
positive regulation of transcription, DNA-templated
negative regulation of canonical Wnt signaling pathway
positive regulation of extracellular matrix assembly
negative regulation of ubiquitin protein ligase activity
negative regulation of double-strand break repair via homologous recombination
negative regulation of cell-cell adhesion mediated by cadherin
positive regulation of double-strand break repair via nonhomologous end joining
mitotic spindle assembly checkpoint
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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