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Invitrogen
Growth Hormone Receptor Recombinant Rabbit Monoclonal Antibody (JU01-34)
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FIGURE: 1 / 6
Growth Hormone Receptor Antibody (MA5-32831) in ICC/IF
Immunocytochemical analysis of Growth Hormone Receptor in SH-SY5Y cells using a Growth Hormone Receptor Monoclonal antibody (Product # MA5-32831) as seen in green. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-32831
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JU01-34
Immunogen
Synthetic peptide within Human Growth hormone receptor aa 537-586.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Growth hormone receptor (GHR) is a gene located on chromosome 5p13.1, encoding a transmembrane receptor that plays a critical role in mediating the effects of growth hormone, which is crucial for growth, metabolism, and tissue development. GHR is expressed in various tissues, including the liver, muscle, and adipose tissue, and facilitates the growth hormone signaling pathway by binding to growth hormone, leading to receptor dimerization and activation of intracellular signaling cascades such as the JAK2-STAT5 pathway. This signaling promotes growth and anabolic processes, influencing body composition, insulin sensitivity, and lipid metabolism. Mutations or alterations in the GHR gene can lead to growth disorders like Laron syndrome, characterized by insensitivity to growth hormone. Understanding GHR's structure and function is pivotal for developing therapeutic strategies for growth deficiencies and metabolic syndromes, as modifying GHR signaling pathways can offer potential interventions in related conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GH receptor; GHRD56; missing exon5 and 6; growth hormone binding protein; growth hormone receptor; growth hormone receptor precursor; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor variant d5-6; growth hormone receptor/binding protein; growth hormone receptor/binding protein precursor; growth hormone receptor/binding protein, high molecular weight; growth hormone receptor/binding protein, low molecular weight; MGC124963; MGC156665; mutant growth hormone receptor; serum binding protein; somatotropin receptor; unnamed protein product
Gene Aliases: GHBP; GHIP; GHR/BP
UniProt ID: (Human) P10912, (Mouse) P16882, (Rat) P16310
Entrez Gene ID: (Human) 2690, (Mouse) 14600, (Rat) 25235
cytokine receptor activity
growth hormone receptor activity
protein binding
lipid binding
peptide hormone binding
growth factor binding
protein kinase binding
protein phosphatase binding
cytokine binding
protein tyrosine kinase activator activity
SH2 domain binding
identical protein binding
protein homodimerization activity
proline-rich region binding
protein tyrosine kinase binding
JAK-STAT cascade
positive regulation of cell proliferation
response to gravity
response to hormone
hormone-mediated signaling pathway
cytokine-mediated signaling pathway
taurine metabolic process
receptor internalization
response to food
regulation of response to nutrient levels
response to estradiol
cellular response to insulin stimulus
cellular response to hormone stimulus
response to cytokine
regulation of multicellular organism growth
positive regulation of multicellular organism growth
hormone metabolic process
positive regulation of MAPK cascade
response to peptide hormone
positive regulation of cell differentiation
positive regulation of JAK-STAT cascade
response to cycloheximide
insulin-like growth factor receptor signaling pathway
response to glucocorticoid
cartilage development involved in endochondral bone morphogenesis
growth hormone receptor signaling pathway
response to growth hormone
response to interleukin-1
activation of Janus kinase activity
proteasome-mediated ubiquitin-dependent protein catabolic process
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of growth hormone receptor signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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