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Invitrogen

AKR1C1 Monoclonal Antibody (5-F10)

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AKR1C1 Monoclonal Antibody (5-F10)

Product Details

MA5-32842

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

5-F10

Immunogen

Recombinant protein within Human AKR1C1 aa 180-323.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 50% Glycerol, 0.2% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2802489

Target Information

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 17-beta-HSD 5; 17HSD type 5; 20 alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD; 20alpha-hydroxysteroid dehydrogenase; 3beta-hydroxysteroid 3-dehydrogenase; aldo-keto reductase C; Aldo-keto reductase family 1 member C1; aldo-keto reductase family 1, member C1 (aldehyde reductase); chlordecone reductase homolog; Chlordecone reductase homolog HAKRC; DD1; Dihydrodiol dehydrogenase 1; dihydrodiol dehydrogenase 1/2; dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase; Estradiol 17 beta-dehydrogenase 5; estradiol 17-beta-dehydrogenase (A-specific); HBAB; hepatic dihydrodiol dehydrogenase; High-affinity hepatic bile acid-binding protein; hydroxysteroid 17-beta dehydrogenase 5; indanol dehydrogenase; oxidoreductase; RP11-69D4.1; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type II 3-alpha-hydroxysteroid dehydrogenase; unnamed protein product

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Gene Aliases: 2-ALPHA-HSD; 20-ALPHA-HSD; 3alpha-HSD; AKR1C1; Akr1c6; C9; DD1; DD1/DD2; DDH; DDH1; H-37; HAKRC; HBAB; Hsd17b5; MBAB

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UniProt ID: (Human) Q04828, (Mouse) P70694

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Entrez Gene ID: (Human) 1645, (Mouse) 83702

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Function(s)
alditol:NADP+ 1-oxidoreductase activity estradiol 17-beta-dehydrogenase activity protein binding alcohol dehydrogenase (NADP+) activity oxidoreductase activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor testosterone dehydrogenase [NAD(P)] activity carboxylic acid binding bile acid binding 3-beta-hydroxy-5-beta-steroid dehydrogenase (NADP+) activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity androsterone dehydrogenase activity 5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity androstan-3-alpha,17-beta-diol dehydrogenase activity testosterone 17-beta-dehydrogenase (NADP+) activity ketosteroid monooxygenase activity trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity indanol dehydrogenase activity 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] activity C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity retinal dehydrogenase activity aldo-keto reductase (NADP) activity isocitrate dehydrogenase activity mevaldate reductase activity gluconate dehydrogenase activity steroid dehydrogenase activity epoxide dehydrogenase activity 5-exo-hydroxycamphor dehydrogenase activity 2-hydroxytetrahydrofuran dehydrogenase activity acetoin dehydrogenase activity phenylcoumaran benzylic ether reductase activity D-xylose:NADP reductase activity L-arabinose:NADP reductase activity D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity steroid dehydrogenase activity, acting on the CH-CH group of donors (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 3-hydroxymenthone dehydrogenase activity very long-chain-3-hydroxyacyl-CoA dehydrogenase activity dihydrotestosterone 17-beta-dehydrogenase activity (R)-2-hydroxyisocaproate dehydrogenase activity L-arabinose 1-dehydrogenase (NADP+) activity L-xylulose reductase (NAD+) activity 3-ketoglucose-reductase activity (R)-2-hydroxyglutarate dehydrogenase activity D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity oxidoreductase reductase metabolite interconversion enzyme
Process(es)
retinoid metabolic process alcohol metabolic process lipid metabolic process prostaglandin metabolic process xenobiotic metabolic process digestion steroid metabolic process bile acid metabolic process bile acid and bile salt transport intestinal cholesterol absorption epithelial cell differentiation monocarboxylic acid metabolic process hormone metabolic process progesterone metabolic process retinal metabolic process cholesterol homeostasis daunorubicin metabolic process doxorubicin metabolic process cellular response to jasmonic acid stimulus positive regulation of reactive oxygen species metabolic process steroid biosynthetic process response to drug response to estrogen negative regulation of mRNA splicing, via spliceosome oxidation-reduction process
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