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Invitrogen
DOPA Decarboxylase Recombinant Rabbit Monoclonal Antibody (JA53-16)
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Product Details
MA5-32853
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JA53-16
Immunogen
Synthetic peptide within Human DOPA Decarboxylase aa 27-76.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
DOPA Decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AADC; Aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase); dopa decarboxylase (aromatic L-amino acid decarboxylase) isoform DDC_1; dopa decarboxylase (aromatic L-amino acid decarboxylase) isoform DDC_2; HGNC:2719; L-Dopa decarboxylase; unnamed protein product
Gene Aliases: AADC; DDC
UniProt ID: (Human) P20711, (Mouse) O88533, (Rat) P14173
Entrez Gene ID: (Human) 1644, (Mouse) 13195, (Rat) 24311
aromatic-L-amino-acid decarboxylase activity
protein binding
lyase activity
carbon-carbon lyase activity
carboxy-lyase activity
enzyme binding
pyridoxal phosphate binding
5-hydroxy-L-tryptophan decarboxylase activity
L-dopa decarboxylase activity
catalytic activity
amino acid binding
protein domain specific binding
decarboxylase
kidney development
cellular amino acid metabolic process
catecholamine metabolic process
response to toxic substance
gene expression
carboxylic acid metabolic process
cellular biogenic amine biosynthetic process
dopamine biosynthetic process
catecholamine biosynthetic process
serotonin biosynthetic process
aminergic neurotransmitter loading into synaptic vesicle
circadian rhythm
multicellular organism aging
isoquinoline alkaloid metabolic process
cellular response to drug
dopamine metabolic process
response to pyrethroid
phytoalexin metabolic process
cellular response to alkaloid
cellular response to growth factor stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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