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Invitrogen
Catenin alpha-1 Recombinant Rabbit Monoclonal Antibody (9O1V3)
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FIGURE: 1 / 2
Catenin alpha-1 Antibody (MA5-35193) in WB
Western blot analysis of Catenin alpha-1 in extracts of various cell lines. Samples were incubated with Catenin alpha-1 Monoclonal antibody (Product # MA5-35193) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35193
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9O1V3
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human alpha-Catenin (P35221)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.27 mg/mL
Amount
27 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MTAVHAGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK KRGRSKKAHV LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVEDVRKQ
Target Information
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 102 kDa cadherin-associated protein; alpha E-catenin; alpha-E-catenin; cadherin associated protein; cadherin-associated protein; CAP102; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha-1-like; epididymis secretory sperm binding protein; renal carcinoma antigen NY-REN-13; unnamed protein product
Gene Aliases: 2010010M04Rik; CAP102; Catna1; MDBS2; MDPT2
UniProt ID: (Human) P35221, (Mouse) P26231
Entrez Gene ID: (Human) 1495, (Rat) 307505, (Mouse) 12385
ovarian follicle development
cell adhesion
establishment or maintenance of cell polarity
negative regulation of neuroblast proliferation
protein localization
male gonad development
gap junction assembly
cell migration
axon regeneration
regulation of cell proliferation
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
apical junction assembly
response to estrogen
positive regulation of smoothened signaling pathway
cellular response to indole-3-methanol
epithelial cell-cell adhesion
cell-cell adhesion
negative regulation of protein localization to nucleus
negative regulation of cell motility
negative regulation of integrin-mediated signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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