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Invitrogen
Aurora B Recombinant Rabbit Monoclonal Antibody (3C4V8)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35292
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
3C4V8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Aurora B (NP_0042082)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAQKENSYPW PYGRQTAPSG LSTLPQRVLR KEPVTPSALV LMSRSNVQPT AAPGQKVMEN SSGTPDILTR HFTIDDFEIG RPLGKGKFGN VYLAREKKSH
Target Information
The Aurora kinases associate with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AIM-1; ARK-2; aurora 1; aurora B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and IPL1-like midbody-associated protein 1; aurora- and Ipl1-like midbody-associated protein 1 homolog; aurora-1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; unnamed protein product
Gene Aliases: AIK2; AIM-1; AIM1; AIRK2; ARK-2; ARK2; AurB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK-1; STK12; STK5
UniProt ID: (Human) Q96GD4, (Rat) O55099, (Mouse) O70126
Entrez Gene ID: (Human) 9212, (Rat) 114592, (Mouse) 20877
negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
chromatin remodeling
spindle organization
mitotic spindle organization
positive regulation of microtubule depolymerization
positive regulation of telomere maintenance
regulation of cytokinesis
negative regulation of cytokinesis
positive regulation of cytokinesis
protein localization to kinetochore
cellular response to UV
cleavage furrow formation
post-translational protein modification
cell cycle G2/M phase transition
mitotic cytokinesis checkpoint
negative regulation of innate immune response
mitotic spindle midzone assembly
midbody abscission
positive regulation of mitotic sister chromatid segregation
negative regulation of protein localization to chromatin
repair of mitotic kinetochore microtubule attachment defect
negative regulation of cGAS/STING signaling pathway
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore
mitotic sister chromatid biorientation
mitotic cell cycle
mitotic cytokinesis
regulation of microtubule-based process
regulation of chromosome segregation
positive regulation of cell cycle process
positive regulation of mitotic cell cycle spindle assembly checkpoint
mitotic spindle assembly
regulation of signal transduction by p53 class mediator
positive regulation of mitotic sister chromatid separation
positive regulation of attachment of mitotic spindle microtubules to kinetochore
positive regulation of mitotic cytokinesis
positive regulation of protein phosphorylation
attachment of mitotic spindle microtubules to kinetochore
cGAS/STING signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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