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Invitrogen
Caspase 6 Recombinant Rabbit Monoclonal Antibody (2W4G2)
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FIGURE: 1 / 6
Caspase 6 Antibody (MA5-35299) in ICC/IF
Immunofluorescence analysis of Casp6 was performed using 70% confluent log phase OVCAR-3 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labelled with Caspase 6 Recombinant Rabbit Monoclonal Antibody (ARC0038) (Product # MA5-35299) at 1:100 dilution in 0.1% BSA, i... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-35299
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
2W4G2
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human Caspase-6 (P55212)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.66 mg/mL
Amount
66 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: IHEVSTVSHA DADCFVCVFL SHGEGNHIYA YDAKIEIQTL TGLFKGDKCH SLVGKPKIFI IQACRGNQHD VPVIPLDVVD NQTEKLDTNI TEVDAASVYT L
Target Information
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; mammalian Ced-3 homologue 2; mCASP-6; unnamed protein product
Gene Aliases: CASP-6; caspase-6; CSP-6; MCH2
UniProt ID: (Human) P55212, (Mouse) O08738
Entrez Gene ID: (Human) 839, (Mouse) 12368
activation of innate immune response
proteolysis
apoptotic process
protein autoprocessing
epithelial cell differentiation
positive regulation of apoptotic process
regulation of programmed cell death
positive regulation of neuron apoptotic process
protein maturation
positive regulation of necroptotic process
pyroptosis
intrinsic apoptotic signaling pathway by p53 class mediator
cellular response to staurosporine
hepatocyte apoptotic process
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
acute inflammatory response to non-antigenic stimulus
axonal fasciculation
response to glucose
response to iron ion
response to cytokine
response to hydrogen peroxide
regulation of apoptotic process
positive regulation of retinal cell programmed cell death
positive regulation of release of cytochrome c from mitochondria
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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