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Invitrogen
NRF1 Recombinant Rabbit Monoclonal Antibody (4Q4E7)
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FIGURE: 1 / 4
NRF1 Antibody (MA5-35366) in IHC (P)
Immunohistochemistry analysis of NRF1 in paraffin-embedded human colon. Samples were incubated with NRF1 Monoclonal antibody (Product # MA5-35366) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
MA5-35366
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
4Q4E7
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human NRF1 (Q16656)
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Amount
80 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LVPSQTVVQT FSNPDGTVSL IQVGTGATVA TLADASELPT TVTVAQVNYS AVADGEVEQN WATLQGGEMT IQTTQASEAT QAVASLAEAA VAASQEMQQG A
Target Information
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Alpha palindromic-binding protein; Alpha-pal; EWG; NRF-1; Nuclear respiratory factor 1; nuclear respiratory factor-1; unnamed protein product
Gene Aliases: ALPHA-PAL; C87038; D6Ertd415e; Nfe2l1_retired; NRF1
UniProt ID: (Human) Q16656, (Mouse) Q9WU00
Entrez Gene ID: (Human) 4899, (Rat) 312195, (Mouse) 18181
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
molecular_function
DNA-binding transcription factor
regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
response to hypoxia
transcription, DNA-templated
mitochondrion organization
organ regeneration
response to estradiol
response to lipopolysaccharide
response to folic acid
response to electrical stimulus
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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