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Invitrogen
CASK Monoclonal Antibody (A1C7)
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FIGURE: 1 / 4
CASK Antibody (MA5-36120) in IHC (P)
Immunohistochemical analysis of CASK in paraffin-embedded human prostate cancer tissue using a monoclonal antibody (Product #MA5-36120). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:50) for 30 mi... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-36120
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
A1C7
Immunogen
Recombinant protein within Human CASK aa 311-513.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member. CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium/calmodulin-dependent serin protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; CAMGUK protein; CASK; membrane associated guanylate kinase; MGC7449; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; peripheral plasma membrane protein CASK-like; protein lin-2 homolog; RP23-278L4.1; trinucleotide repeat containing 8; unnamed protein product
Gene Aliases: CAGH39; CAMGUK; CMG; DXPri1; DXRib1; FGS4; hCASK; LIN-2; LIN2; MICPCH; mLin-2; MRXSNA; Pals3; TNRC8
UniProt ID: (Human) O14936, (Mouse) O70589, (Rat) Q62915
Entrez Gene ID: (Human) 8573, (Mouse) 12361, (Rat) 29647
negative regulation of cell-matrix adhesion
regulation of transcription from RNA polymerase II promoter
protein localization
negative regulation of keratinocyte proliferation
protein transport
positive regulation of insulin secretion
positive regulation of transcription from RNA polymerase II promoter
regulation of neurotransmitter secretion
positive regulation of transport
positive regulation of dendritic spine morphogenesis
negative regulation of wound healing
calcium ion import
protein localization to plasma membrane
positive regulation of calcium ion import
negative regulation of cellular response to growth factor stimulus
regulation of synaptic vesicle exocytosis
cell adhesion
GMP metabolic process
GDP metabolic process
cerebral cortex development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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