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Invitrogen
MSH2 Recombinant Rabbit Monoclonal Antibody (JE28-48)
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FIGURE: 1 / 3
MSH2 Antibody (MA5-36171) in IHC (P)
Immunohistochemical analysis of MSH2 in paraffin-embedded human colon carcinoma tissue using a monoclonal antibody (Product #MA5-36171). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:50) for 30 mi... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-36171
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE28-48
Immunogen
Synthetic peptide within human msh2 aa 1-100 (n terminal).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA mismatch repair protein Msh2 transcript; Frameshift mutation results in premature stop; homolog of bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345]; germline mutations are responsible for hereditary nonpolyposis colon cancer (HNPCC); homolog of S. cerevisiae Msh2p [Swiss-Prot accession number P25847] and bacterial MutS proteins [Swiss-Prot accession numbers P23909, P10339, and P27345]; Insertion mutation results in premature stop; Msh2p; mutation causes premature stop; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS-like 2; premature stop codon due to mutation; The base insertion results in premature stop; The deletion results in premature stop.; unnamed protein product
Gene Aliases: COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; LYNCH1; MMRCS2; MSH-2
UniProt ID: (Human) P43246
Entrez Gene ID: (Human) 4436
magnesium ion binding
four-way junction DNA binding
DNA binding
chromatin binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
protein binding
ATP binding
enzyme activator activity
DNA-dependent ATPase activity
ATPase activity
centromeric DNA binding
mismatched DNA binding
guanine/thymine mispair binding
dinucleotide insertion or deletion binding
single guanine insertion binding
single thymine insertion binding
dinucleotide repeat insertion binding
oxidized purine DNA binding
MutLalpha complex binding
protein homodimerization activity
ADP binding
ATP-dependent DNA damage sensor activity
somatic recombination of immunoglobulin genes involved in immune response
DNA repair
mismatch repair
postreplication repair
mitotic recombination
male gonad development
response to X-ray
response to UV-B
somatic recombination of immunoglobulin gene segments
B cell mediated immunity
B cell differentiation
negative regulation of neuron apoptotic process
maintenance of DNA repeat elements
isotype switching
negative regulation of DNA recombination
positive regulation of isotype switching to IgA isotypes
positive regulation of isotype switching to IgG isotypes
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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