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Invitrogen

Phospho-p38 MAPK alpha (Thr180, Tyr182) Recombinant Rabbit Monoclonal Antibody (P38T180Y182-E3)

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Phospho-p38 MAPK alpha (Thr180, Tyr182) Recombinant Rabbit Monoclonal Antibody (P38T180Y182-E3)

Product Details

MA5-36911

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1-1,000 ng/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

P38T180Y182-E3

Immunogen

A synthetic phospho-peptide corresponding to residues surrounding Thr180/Tyr182 of human phospho p38 MAPK.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS with 50% glycerol, 0.10% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2896846

Target Information

MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; cytokine-supressive anti-inflammatory drug binding protein; EC 2.7.11.24; encoded by transcript variant 4; p38 MAP kinase; encoded by transcript variant 5; p38 MAP kinase; ERK1; ERT2; MAP 14; MAP kinase 1; MAP kinase 14; MAP kinase 2; MAP kinase Mxi2; MAP kinase p38; MAP kinase p38 alpha; MAP kinase p38alpha; MAPK 14; MAPK1 antibody; MAPK14; MAX-interacting protein 2; mitogen-activated protein kinase 14A; mitogen-activated protein kinase p38 alpha; MK14; OTTHUMP00000216563; OTTHUMP00000216566; p38 MAP kinase; p38 MAP kinase alpha; p38 MAPK; p38 mitogen activated protein kinase; p38alpha Exip; reactive kinase; RP1-179N16.5; SAPK2a; CSAIDS binding protein 1; stress-activated protein kinase 2A; unnamed protein product

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Gene Aliases: CRK1; CSBP; CSBP1; CSBP2; CSPB1; EXIP; Hog; Mxi2; p38; p38-alpha; p38a; p38ALPHA; p38Hog; p38MAPK; PRKM14; PRKM15; RK; SAPK2A

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UniProt ID: (Human) Q16539, (Mouse) P47811

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Entrez Gene ID: (Human) 1432, (Mouse) 26416, (Rat) 81649

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Function(s)
protein kinase activity protein serine/threonine kinase activity MAP kinase activity MAP kinase kinase activity protein binding ATP binding enzyme binding protein phosphatase binding mitogen-activated protein kinase p38 binding NFAT protein binding protein serine kinase activity kinase activity
Process(es)
MAPK cascade negative regulation of inflammatory response to antigenic stimulus regulation of transcription from RNA polymerase II promoter chemotaxis signal transduction cell surface receptor signaling pathway positive regulation of gene expression positive regulation of myotube differentiation platelet activation osteoclast differentiation stress-activated protein kinase signaling cascade positive regulation of cyclase activity positive regulation of interleukin-12 production negative regulation of hippo signaling intracellular signal transduction cellular response to vascular endothelial growth factor stimulus p38MAPK cascade signal transduction in response to DNA damage positive regulation of blood vessel endothelial cell migration positive regulation of erythrocyte differentiation positive regulation of myoblast differentiation vascular endothelial growth factor receptor signaling pathway positive regulation of muscle cell differentiation stress-activated MAPK cascade 3'-UTR-mediated mRNA stabilization cellular response to lipopolysaccharide cellular response to lipoteichoic acid cellular response to ionizing radiation cellular response to UV-B cellular senescence stress-induced premature senescence cellular response to virus regulation of cytokine production involved in inflammatory response positive regulation of myoblast fusion positive regulation of reactive oxygen species metabolic process DNA damage checkpoint cell morphogenesis cartilage condensation angiogenesis osteoblast differentiation placenta development response to dietary excess chondrocyte differentiation glucose metabolic process regulation of transcription, DNA-templated protein phosphorylation cellular response to DNA damage stimulus transmembrane receptor protein serine/threonine kinase signaling pathway skeletal muscle tissue development myoblast differentiation involved in skeletal muscle regeneration peptidyl-serine phosphorylation fatty acid oxidation regulation of ossification lipopolysaccharide-mediated signaling pathway response to muramyl dipeptide response to lipopolysaccharide response to insulin tumor necrosis factor-mediated signaling pathway response to muscle stretch positive regulation of protein import into nucleus positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import protein autophosphorylation striated muscle cell differentiation protein maturation regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation bone development pyroptosis cellular response to tumor necrosis factor negative regulation of canonical Wnt signaling pathway positive regulation of brown fat cell differentiation regulation of synaptic membrane adhesion NLRP1 inflammasome complex assembly response to glucose phosphorylation cellular response to transforming growth factor beta stimulus cellular response to acetaldehyde
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