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Invitrogen

GNAS Monoclonal Antibody (559CT 16.1.3)

View all (25) GNAS antibodies

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Product Details

MA5-37599

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

559CT 16.1.3

Immunogen

KLH conjugated synthetic peptide between 287-315 amino acids from human GNAS

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897527

Target Information

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenylate cyclase-stimulating G alpha protein; alternative gene product encoded by XL-exon; dJ309F20.1.1; dJ806M20.3.3; extra large alphas protein; G protein; G protein subunit alpha S; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; GNSA1; Gs alpha subunit; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; guanine nucleotide-binding protein alpha subunit; MGC33735; NESP55; large dense core vesicle secretory protein; neuroendocrine secretory protein 55; NTas; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; PHP1C; RP4-543J19.4; secretogranin VI; stimulatory G protein of adenylate cyclase, alpha chain; stimulatory G-protein alpha subunit; unnamed protein product; XL2; XLas

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Gene Aliases: 5530400H20Rik; A930027G11Rik; AHO; AIMAH1; C130027O20Rik; C20orf45; Galphas; GNAS1; Gnasxl; GPSA; Gs-alpha; GSA; GSP; NESP; Nesp55; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; PITA3; POH; SCG6; SgVI

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UniProt ID: (Human) O95467, (Mouse) P63094

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Entrez Gene ID: (Human) 2778, (Mouse) 14683

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Function(s)
GTPase activity obsolete small monomeric GTPase activity insulin-like growth factor receptor binding protein binding GTP binding adenylate cyclase activator activity guanyl nucleotide binding G-protein beta/gamma-subunit complex binding beta-2 adrenergic receptor binding D1 dopamine receptor binding mu-type opioid receptor binding ionotropic glutamate receptor binding corticotropin-releasing hormone receptor 1 binding G-protein alpha-subunit binding adenylate cyclase regulator activity protein domain specific binding G-protein beta-subunit binding alpha-tubulin binding alkylglycerophosphoethanolamine phosphodiesterase activity
Process(es)
skeletal system development cellular glucose homeostasis tissue homeostasis positive regulation of protein phosphorylation endochondral ossification energy reserve metabolic process regulation of transcription from RNA polymerase II promoter signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway adenylate cyclase-activating dopamine receptor signaling pathway adenylate cyclase-activating serotonin receptor signaling pathway sensory perception of chemical stimulus positive regulation of cell proliferation response to xenobiotic stimulus post-embryonic development regulation of signal transduction positive regulation of sodium ion transport regulation of skeletal muscle contraction response to prostaglandin E embryonic hindlimb morphogenesis multicellular organism growth positive regulation of insulin secretion involved in cellular response to glucose stimulus cell surface bile acid receptor signaling pathway negative regulation of multicellular organism growth post-embryonic body morphogenesis skin development positive regulation of osteoblast differentiation positive regulation of osteoclast differentiation negative regulation of blood pressure developmental growth embryonic cranial skeleton morphogenesis positive regulation of phagocytosis cognition cartilage development bone development hair follicle placode formation platelet aggregation response to parathyroid hormone cellular response to glucagon stimulus cellular response to prostaglandin E stimulus cellular response to acidic pH genetic imprinting cellular response to catecholamine stimulus adenylate cyclase-activating adrenergic receptor signaling pathway positive regulation of cold-induced thermogenesis regulation of parathyroid hormone secretion ovarian follicle development negative regulation of inflammatory response to antigenic stimulus renal water homeostasis activation of adenylate cyclase activity female pregnancy sensory perception of smell protein secretion positive regulation of insulin secretion intracellular transport vascular endothelial cell response to laminar fluid shear stress
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