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Invitrogen
FDPS Monoclonal Antibody (1049CT13.1.4)
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FIGURE: 1 / 1
FDPS Antibody (MA5-37752) in WB
Western Blot analysis of FDPS using the FDPS Monoclonal Antibody (Product # MA5-37752) at a 1:2000-1:4000 dilution. Lane 1: Hela whole cell lysate, Lane 2: HepG2 whole cell lysate, Lane 3: U-251 MG whole cell lysate, Lane 4: Mouse Liver lysate. Lysates/proteins were loaded at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1:10,000 dilution. Predicted band size : 40, 48 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
MA5-37752
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
1049CT13.1.4
Immunogen
recombinant protein of human FDPS
Conjugate
Form
Liquid
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The isoprene biosynthetic pathway supply the cell with cholesterol, ubiquinone, and various nonsterol metabolites. The farnesylpyrophosphate synthetase enzyme catalyzes the formation of geranyl and farnesylpyrophosphate from isopentenylpyrophosphate and dimethylallyl pyrophosphate. Analysis of FDPS activity and protein in rat liver, accompanied by immunofluorescence and immunoelectron microscopy studies, demonstrated that FDPS is predominantly localized in peroxisomes. 1 Liver tissue from patients with the peroxisomal deficiency diseases Zellweger syndrome and neonatal adrenoleukodystrophy exhibit diminished activities of FDPS and subsequent isoprenoid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: (2E,6E)-farnesyl diphosphate synthase; Cholesterol-regulated 39 kDa protein; CR 39; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; farnesyl pyrophosphate synthetase; farnesyl pyrophosphate synthetase (EC 2.5.1.1); farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase; FPP synthase; FPP synthetase; FPS; Geranyltranstransferase; KIAA1293; unnamed protein product
Gene Aliases: 6030492I17Rik; AI256750; FDPS; Fdpsl1; FPPS; FPS; KIAA1293; mKIAA1293; POROK9
UniProt ID: (Human) P14324, (Mouse) Q920E5
Entrez Gene ID: (Human) 2224, (Mouse) 110196
lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
steroid metabolic process
cholesterol metabolic process
isoprenoid biosynthetic process
sterol biosynthetic process
geranyl diphosphate biosynthetic process
farnesyl diphosphate biosynthetic process
positive regulation of cholesterol biosynthetic process
positive regulation of cell growth involved in cardiac muscle cell development
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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