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Invitrogen

PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (5K0F4)

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PGC1 alpha/beta Recombinant Rabbit Monoclonal Antibody (5K0F4)

Product Details

MA5-37948

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:6,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

5K0F4

Immunogen

Synthetic peptide
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

200 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897868

Product Specific Information

Positive Samples: Mouse liver, Rat heart

Immunogen sequence: VFGEIEECTV NLRDDGDSYG FITYRYTCDA FAALENGYTL RRSNETDFEL YFCGRKQFFK SNYADLDSNS DDFDPASTKS KYDSLDFDSL LKEAQRSLRR

Target Information

PGC-1 beta is a tissue specific co-activator that enhances the activity of estrogen receptor alpha. The co-activation function relies on a bipartite transcriptional activation domain and two LXXLL motifs that interact with the AR2 domain of ER-alpha in an estrogen-dependent manner. Ectopic expression of this protein has been shown to lead to increased mitochondrial number and basal oxygen consumption.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ERR ligand 1; L-PGC-1alpha; ligand effect modulator-6; PERC; PERC-s; lacks one estrogen receptor interaction domain; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1; pgc-1 alpha; pgc-1 beta; PGC-1-alpha; PGC-1-beta; PGC-1-related estrogen receptor alpha coactivator; PGC-1alpha; PGC1beta-1a; PGC1beta-1b; PGC1beta-2a; PGC1beta-2b; PPAR gamma coactivator 1alpha variant form-1; PPAR gamma coactivator variant form; PPAR gamma coactivator-1beta protein; PPAR-gamma coactivator 1-alpha; PPAR-gamma coactivator 1-beta; PPARAGCIalpha; PPARAGCIbeta; PPARgamma coactivator 1 beta; PPARgamma coactivator 1alpha; PPARGC-1-alpha; PPARGC-1-beta; Ppargc1a-vf1; transcriptional coactivator; transcriptional coactivator; PGC-1; unnamed protein product

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Gene Aliases: 4631412G21Rik; A830037N07Rik; ERRL1; Gm11133; LEM6; LRPGC1; PERC; PGC-1; PGC-1(alpha); PGC-1(beta); PGC-1alpha; PGC-1beta; PGC-1beta/ERRL1; PGC-1v; PGC1; PGC1A; PGC1B; PGC1beta; Pgco1; PGCvf; PGCvf-1; PGCvf1; PPARGC-1-alpha; PPARGC-1-beta; PPARGC1

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UniProt ID: (Human) Q9UBK2, (Human) Q86YN6, (Mouse) O70343, (Rat) Q9QYK2, (Mouse) Q8VHJ7, (Rat) Q811R2

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Entrez Gene ID: (Human) 10891, (Human) 133522, (Mouse) 19017, (Rat) 83516, (Mouse) 170826, (Rat) 291567

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Function(s)
nucleic acid binding DNA binding transcription cofactor activity transcription coactivator activity RNA binding protein binding ligand-dependent nuclear receptor binding chromatin DNA binding ubiquitin protein ligase binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding lncRNA binding DNA-binding transcription factor binding estrogen receptor binding AF-2 domain binding chromatin binding peroxisome proliferator activated receptor binding alpha-tubulin binding promoter-specific chromatin binding
Process(es)
negative regulation of protein phosphorylation response to dietary excess gluconeogenesis regulation of transcription, DNA-templated mitochondrion organization positive regulation of gene expression response to activity response to muscle activity negative regulation of smooth muscle cell migration respiratory electron transport chain developmental process circadian regulation of gene expression cellular response to oxidative stress regulation of circadian rhythm negative regulation of neuron apoptotic process positive regulation of gluconeogenesis negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation negative regulation of smooth muscle cell proliferation multicellular organismal homeostasis adipose tissue development cellular response to follicle-stimulating hormone stimulus cellular response to transforming growth factor beta stimulus negative regulation of mitochondrial fission energy homeostasis cellular response to thyroid hormone stimulus positive regulation of cold-induced thermogenesis positive regulation of glomerular visceral epithelial cell apoptotic process positive regulation of vascular smooth muscle cell proliferation positive regulation of progesterone biosynthetic process negative regulation of receptor activity regulation of N-methyl-D-aspartate selective glutamate receptor activity intracellular estrogen receptor signaling pathway positive regulation of osteoclast differentiation response to nutrient response to glucocorticoid response to cAMP temperature homeostasis cellular glucose homeostasis transcription initiation from RNA polymerase II promoter mRNA processing digestion RNA splicing fatty acid oxidation response to starvation cellular respiration protein stabilization brown fat cell differentiation protein-containing complex assembly response to reactive oxygen species mitophagy response to hypoxia response to ischemia galactose metabolic process response to xenobiotic stimulus response to fructose skeletal muscle atrophy response to electrical stimulus involved in regulation of muscle adaptation cerebellum development forebrain development response to nutrient levels cellular response to potassium ion response to leucine response to morphine response to electrical stimulus cellular response to lipopolysaccharide cellular response to nitrite cellular response to caffeine cellular response to fructose stimulus cellular response to glucose stimulus cellular response to interleukin-6 cellular response to tumor necrosis factor cellular response to estradiol stimulus cellular response to fatty acid cellular response to hypoxia response to epinephrine response to norepinephrine response to thyroid hormone response to dehydroepiandrosterone cellular response to ionomycin cellular response to resveratrol response to methionine adaptive thermogenesis response to hypobaric hypoxia
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