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Invitrogen
USP9X Recombinant Rabbit Monoclonal Antibody (7T0S2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-38217
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7T0S2
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human USP9X (Q93008)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.37 mg/mL
Amount
37 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: 293T, PC-3, C6, U-251MG, Mouse testis, Mouse brain
Immunogen sequence: MTATTRGSPV GGNDNQGQAP DGQSQPPLQQ NQTSSPDSSN ENSPATPPDE QGQGDAPPQL EDEEPAFPHT DLAKLDDMIN RPRWVVPVLP KGELEVLLEA
Target Information
USP9X is an ubiquitin-specific protease involved in the removal and recycling of ubiquitin from proteins degraded in proteasomes. As a deubiquitinating enzyme, USP9x has a critical function in tight junction biogenesis by controlling the levels of the exchange factor for Arf6 (EFA6), a protein shown to facilitate tight junction formation during a narrow temporal window preceding the establishment of cell polarity. USP9X is also located on the X-chromosome but escapes X-inactivation, and defects in USP9X may cause gonadal degeneration in Turner syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: deubiquitinating enzyme FAF-X; Drosophila fat facets related, X-linked; fat facets homolog; fat facets in mammals; fat facets protein related, X-linked; fat facets protein-related, X-linked; fat facets-like, X-linked; fats facets protein related, X; probable ubiquitin carboxyl-terminal hydrolase FAF-X; similar to Homo sapiens ubiquitin hydrolase encoded by GenBank Accession Number X98296; ubiquitin carboxyl-terminal hydrolase FAM; ubiquitin specific peptidase 9, X chromosome; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; ubiquitin-specific protease 9, X chromosome; ubiquitin-specific-processing protease FAF-X; unknown; unnamed protein product
Gene Aliases: 5730589N07Rik; DFFRX; FAF; FAF-X; Fafl; FAM; hFAM; MRX99; MRXS99F; RGD1560056; XLID99
UniProt ID: (Human) Q93008, (Mouse) P70398
Entrez Gene ID: (Human) 8239, (Rat) 363445, (Mouse) 22284
cysteine-type endopeptidase activity
thiol-dependent ubiquitin-specific protease activity
protein binding
cysteine-type peptidase activity
Lys63-specific deubiquitinase activity
co-SMAD binding
ubiquitinyl hydrolase activity
molecular sequestering activity
K11-linked deubiquitinase activity
Lys48-specific deubiquitinase activity
ubiquitin protein ligase binding
in utero embryonic development
neuron migration
DNA dealkylation involved in DNA repair
transforming growth factor beta receptor signaling pathway
post-embryonic development
cell migration
protein import into peroxisome matrix, receptor recycling
protein deubiquitination
cerebellar cortex structural organization
hippocampus development
BMP signaling pathway
regulation of protein stability
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
monoubiquitinated protein deubiquitination
regulation of circadian rhythm
axon extension
protein stabilization
cilium morphogenesis
cytosolic ciliogenesis
protein K63-linked deubiquitination
cellular response to transforming growth factor beta stimulus
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of postsynapse assembly
positive regulation of TORC2 signaling
neuron projection extension
negative regulation of transcription from RNA polymerase II promoter
female gamete generation
protein localization
protein ubiquitination
positive regulation of protein binding
amyloid fibril formation
protein import into peroxisome matrix
regulation of T cell receptor signaling pathway
negative regulation of cilium assembly
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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