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Phospho-VANGL2 (Thr78, Ser79, Ser82) Recombinant Rabbit Monoclonal Antibody (7H7C2)
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FIGURE: 1 / 1
Phospho-VANGL2 (Thr78, Ser79, Ser82) Antibody (MA5-38241) in WB
Western blot analysis of Phospho-VANGL2 (Thr78, Ser79, Ser82) in extracts of various cell lines. Samples were incubated with Phospho-VANGL2 (Thr78, Ser79, Ser82) Monoclonal antibody (Product # MA5-38241) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. HeLa cells and NIH/3T3 cells and C6 cells were treated by wnt (100 ng/mL) for 30 minutes... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-38241
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
7H7C2
Immunogen
Synthetic peptide
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: HeLa, NIH/3T3, C6
Target Information
Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: loop tail associated protein; loop-tail protein 1; loop-tail protein 1 homolog; loop-tail-associated protein; MGC119403; MGC119404; strabismus 1; unnamed protein product; van Gogh-like protein 2; vang; vang-like 2 (van gogh, Drosophila); vang-like 2 protein
Gene Aliases:
C530001F03Rik; loop-tail; Lootl; Lp; LPP1; LTAP; ska17; ska
UniProt ID: (Human) Q9ULK5, (Rat) P84889, (Mouse) Q91ZD4
Entrez Gene ID: (Human) 57216, (Rat) 289229, (Mouse) 93840
establishment of planar polarity
neural tube closure
heart looping
cell migration involved in kidney development
dopaminergic neuron axon guidance
serotonergic neuron axon guidance
apical protein localization
Wnt signaling pathway, planar cell polarity pathway
non-motile cilium assembly
regulation of synapse pruning
hair follicle development
membranous septum morphogenesis
muscular septum morphogenesis
Rho protein signal transduction
biological_process
anterior/posterior pattern specification
heparan sulfate proteoglycan biosynthetic process
convergent extension involved in neural plate elongation
regulation of Wnt signaling pathway
glomerulus development
regulation of actin cytoskeleton organization
somatic stem cell population maintenance
non-canonical Wnt signaling pathway
post-anal tail morphogenesis
wound healing
positive regulation of JUN kinase activity
establishment or maintenance of epithelial cell apical/basal polarity
somatic stem cell division
establishment of body hair planar orientation
digestive tract morphogenesis
convergent extension involved in axis elongation
convergent extension involved in organogenesis
inner ear receptor cell development
inner ear receptor stereocilium organization
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis
lateral sprouting involved in lung morphogenesis
kidney morphogenesis
cochlea development
cochlea morphogenesis
regulation of establishment of planar polarity
establishment of planar polarity involved in neural tube closure
patterning of blood vessels
outflow tract septum morphogenesis
epicardial cell to mesenchymal cell transition
cardiac vascular smooth muscle cell differentiation
establishment of epithelial cell polarity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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