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Invitrogen

TLR9 Monoclonal Antibody (1B12H2)

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TLR9 Monoclonal Antibody (1B12H2)

Product Details

MA5-38645

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

1:200-1:1,000
-

Flow Cytometry (Flow)

1:200-1:400
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1B12H2

Immunogen

Purified recombinant fragment of human TLR9 (aa: 868-1016) expressed in E. Coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898557

Product Specific Information

This antibody has been tested in indirect ELISA.

Target Information

The protein encoded by this gene is a member of the Toll-like receptor family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD289; orphan receptor; Toll-like receptor 9; unspliced isoform

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Gene Aliases: CD289; TLR9; UNQ5798/PRO19605

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UniProt ID: (Human) Q9NR96

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Entrez Gene ID: (Human) 54106

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Function(s)
interleukin-1 receptor binding siRNA binding pattern recognition receptor activity protein homodimerization activity unmethylated CpG binding
Process(es)
microglial cell activation positive regulation of cytokine production activation of innate immune response toll-like receptor signaling pathway immune system process positive regulation of immunoglobulin production regulation of dendritic cell cytokine production MyD88-dependent toll-like receptor signaling pathway inflammatory response immune response signal transduction I-kappaB kinase/NF-kappaB signaling male gonad development response to virus positive regulation of autophagy positive regulation of gene expression maintenance of gastrointestinal epithelium positive regulation of B cell proliferation positive regulation of type I interferon production detection of molecule of bacterial origin positive regulation of chemokine production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production toll-like receptor 9 signaling pathway positive regulation of toll-like receptor 9 signaling pathway defense response to bacterium positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade innate immune response regulation of B cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium regulation of B cell activation positive regulation of B cell activation defense response to virus negative regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to metal ion defense response to other organism endolysosomal toll-like receptor signaling pathway negative regulation of calcium-transporting ATPase activity cellular response to chloroquine positive regulation of intestinal epithelial cell development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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