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Invitrogen
UHRF1 Monoclonal Antibody (1A1B1)
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FIGURE: 1 / 8
UHRF1 Antibody (MA5-38654) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of UHRF1 in HeLa cells using UHRF1 Monoclonal Antibody (Product # MA5-38654) (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Product # 35503)
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-38654
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1A1B1
Immunogen
Purified recombinant fragment of human UHRF1 (aa: 616-755) expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ac2-121; FLJ21925; Hnp95 Huhrf1; inverted CCAAT box binding protein 90; inverted CCAAT box-binding protein of 90 kDa; MGC138707; nuclear phosphoprotein 95; nuclear protein 95; nuclear zinc finger protein Np95; RING finger protein 106; RING-type E3 ubiquitin transferase UHRF1; thymus and cell proliferation associated protein; transcription factor ICBP90; ub; ubiquitin-like PHD and RING finger domain-containing protein 1; unnamed protein product
Gene Aliases: hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106; TDRD22
UniProt ID: (Human) Q96T88
Entrez Gene ID: (Human) 29128
core promoter proximal region sequence-specific DNA binding
nucleic acid binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
methyl-CpG binding
histone binding
identical protein binding
hemi-methylated DNA-binding
ubiquitin protein ligase activity
histone H3K9me2/3 reader activity
histone H3 reader activity
histone H3K23 ubiquitin ligase activity
histone H3K18 ubiquitin ligase activity
DNA damage sensor activity
histone H3K14 ubiquitin ligase activity
histone H3 ubiquitin ligase activity
negative regulation of transcription from RNA polymerase II promoter
double-strand break repair via homologous recombination
ubiquitin-dependent protein catabolic process
response to stress
cellular response to DNA damage stimulus
protein ubiquitination
heterochromatin assembly
reciprocal DNA recombination
regulation of gene expression, epigenetic
hypermethylation of CpG island
positive regulation of transcription from RNA polymerase II promoter
regulation of epithelial cell proliferation
positive regulation of protein metabolic process
protein autoubiquitination
protein localization to chromatin
mitotic spindle assembly
chromosomal DNA methylation maintenance following DNA replication
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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