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Invitrogen
PDGFRA Monoclonal Antibody (6C7E2)
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FIGURE: 1 / 2
PDGFRA Antibody (MA5-41073) in WB
Western Blot using PDGFRA Monoclonal Antibody (6C7E2) (Product # MA5-41073) at 1:500 dilution. Lane A: 293T Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Mouse IgG H&L (DyLight™ 800) at 1:15,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 123 kDa. Observed band size: 123 kDa.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-41073
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
6C7E2
Immunogen
Recombinant Human PDGFRA/CD140a protein (1-524).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
PDGFRA is a cell surface receptor tyrosine kinase which binds members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140a antigen; MGC74795; OTTHUMP00000218656; PDGF A-chain; PDGF Receptor alpha; PDGF subunit A; PDGF-1; PDGF-R-alpha; pdgfr-a; platelet-derived growth factor receptor 2; platelet-derived growth factor receptor, alpha polypeptide; unnamed protein product
Gene Aliases: CD140A; PDGFR-2; PDGFR2
UniProt ID: (Human) P16234
Entrez Gene ID: (Human) 5156
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
platelet-derived growth factor alpha-receptor activity
vascular endothelial growth factor-activated receptor activity
platelet-derived growth factor receptor binding
protein binding
ATP binding
vascular endothelial growth factor binding
protein homodimerization activity
macromolecular complex binding
platelet-derived growth factor binding
phospholipase C activator activity
luteinization
cell activation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
negative regulation of platelet activation
cell migration
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
regulation of actin cytoskeleton organization
cellular response to reactive oxygen species
platelet-derived growth factor receptor-alpha signaling pathway
peptidyl-tyrosine autophosphorylation
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
wound healing
positive regulation of MAPK cascade
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
positive regulation of fibroblast proliferation
embryonic digestive tract morphogenesis
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
positive regulation of calcium-mediated signaling
positive regulation of chemotaxis
positive regulation of protein kinase B signaling
cardiac myofibril assembly
cell chemotaxis
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
platelet aggregation
metanephric glomerular capillary formation
regulation of mesenchymal stem cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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