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Invitrogen

IL-12 p35 Monoclonal Antibody (C1)

View all (31) IL-12 p35 antibodies

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IL-12 p35 Monoclonal Antibody (C1)

Product Details

MA5-41614

Applications
Tested Dilution
Publications

Western Blot (WB)

0.01-3 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

C1

Immunogen

Recombinant protein Interleukin 12A. The antigen corresponds to amino acid range 23-219 of the target protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

200 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899096

Target Information

Interleukin 12A is a novel signaling cytokine belonging to the Interleukin-6 protein superfamily. Interleukin-12 alpha chain precursor (IL-12A) is a 35-kD subunit of disulfide-linked heterodimer of cytokine IL-12 and has a broad array of biological activities. Reports suggest that IL-12A can act as a growth factor for activated T and NK cells and enhance the lytic activity of NK/lymphokine-activated Killer cells. IL-12A stimulates the production of IFN-gamma by resting PBMC as well as T-cell-independent induction of interferon (IFN)-gamma, and helps in the differentiation of both Th1 and Th2 cells. It is also involved in positive regulation of tyrosine phosphorylation of Stat4 protein. The signaling process of IL-12A in innate immunity requires nitric oxide synthase 2A. Along with EBI3, IL-12A forms a novel heterodimeric cytokine, designated as interleukin-35 (IL-35), that may be specifically produced by T reg cells and is required for maximal suppressive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CLMF p35; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; il 12; IL-12 p35 subunit; IL-12 subunit p35; IL-12, subunit p35; IL12p35; IL35 subunit; ILN; Interleukin; Interleukin 12; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin 12a p35 subunit; interleukin-12 alpha chain; interleukin-12 p35 subunit; Interleukin12; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NKSF/CLMF; IL12p35; 35kD

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Gene Aliases: CLMF; IL-12A; IL-12p35; Ll12a; NFSK; NKSF1; P35

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UniProt ID: (Human) P29459, (Mouse) P43431

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Entrez Gene ID: (Human) 3592, (Mouse) 16159

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Function(s)
cytokine activity interleukin-12 receptor binding protein binding growth factor activity interleukin-12 beta subunit binding interleukin-27 binding protein heterodimerization activity
Process(es)
positive regulation of T cell mediated cytotoxicity negative regulation of T-helper 1 type immune response positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response response to virus response to UV-B cell migration regulation of B cell proliferation response to lipopolysaccharide negative regulation of interleukin-17 production positive regulation of interferon-gamma production positive regulation of natural killer cell activation positive regulation of natural killer cell proliferation positive regulation of mononuclear cell proliferation positive regulation of smooth muscle cell apoptotic process interleukin-12-mediated signaling pathway positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein positive regulation of cell adhesion positive regulation of natural killer cell mediated cytotoxicity positive regulation of JAK-STAT cascade negative regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation negative regulation of protein secretion defense response to Gram-positive bacterium positive regulation of NK T cell activation positive regulation of NK T cell proliferation interleukin-35-mediated signaling pathway extrinsic apoptotic signaling pathway cellular response to virus negative regulation of vascular endothelial growth factor signaling pathway negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of dendritic cell chemotaxis cell proliferation T-helper 1 cell activation defense response to protozoan T-helper 1 cell differentiation positive regulation of T cell differentiation cellular response to lipopolysaccharide
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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