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Invitrogen
NGF (Tanezumab Biosimilar) Recombinant Human Monoclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-41831
Product Specifications
Species Reactivity
Human
Host/Isotype
Human
/ IgG2, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Human IGHE
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
This product is a Humanized mouse antibody.
Target Information
Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B nerve growth factor; b-NGF; beta ngf; BetaNGF; bNGF; MGC161426; MGC161428; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta subunit; NGF b; NGF β; NGFB; NGFbeta; NGFβ; pro-nerve growth factor long; unnamed protein product; β nerve growth factor; β NGF; βNGF
Gene Aliases: Beta-NGF; HSAN5; NGFB
UniProt ID: (Human) P01138
Entrez Gene ID: (Human) 4803
receptor binding
nerve growth factor receptor binding
protein binding
growth factor activity
metalloendopeptidase inhibitor activity
cysteine-type endopeptidase activator activity involved in apoptotic process
transmembrane receptor protein tyrosine kinase activator activity
death receptor agonist activity
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
circadian rhythm
negative regulation of cell proliferation
extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of gene expression
nerve development
nerve growth factor signaling pathway
negative regulation of neuron apoptotic process
positive regulation of neuron differentiation
positive regulation of Ras protein signal transduction
neurotrophin TRK receptor signaling pathway
neuron projection morphogenesis
modulation of synaptic transmission
neuron apoptotic process
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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