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ABH1 Recombinant Rabbit Monoclonal Antibody (JE56-09)
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FIGURE: 1 / 5
ABH1 Antibody (MA5-42511) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded human small intestine tissue using ABH1 Recombinant Monoclonal Antibody (Product # MA5-42511). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the ABH1 antibod... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-42511
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE56-09
Immunogen
Synthetic peptide within C-terminal Human ALKBH1.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Human placenta tissue lysate, MCF-7 cell lysate, Daudi cell lysate, A549 cell lysate, zebrafish tissue lysates, human liver carcinoma tissue, human skin tissue, human small intestine tissue.
Subcellular Location: Mitochondrion, Nucleus.
Target Information
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alkB, alkylation repair homolog 1; alkylated DNA repair protein alkB homolog 1; alkylation repair, alkB homolog; alpha-ketoglutarate-dependent dioxygenase ABH1; DNA 6mA demethylase; DNA demethylase ALKBH1; DNA lyase ABH1; DNA N6-methyl adenine demethylase ALKBH1; DNA oxidative demethylase ALKBH1; mRNA N(3)-methylcytidine demethylase; tRNA N1-methyl adenine demethylase
Gene Aliases: ABH; ABH1; alkB; ALKBH; hABH; si:ch211-133l14.1; zgc:112365
UniProt ID: (Human) Q13686
Entrez Gene ID: (Human) 8846, (Zebrafish) 553720
tRNA binding
ferrous iron binding
oxidative RNA demethylase activity
oxidative DNA demethylase activity
chemoattractant activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DNA N6-methyladenine demethylase activity
2-oxoglutarate-dependent tRNA 5-methylcytidine formyltransferase activity
tRNA demethylase activity
oxidoreductase activity
oxidation-reduction process
tRNA wobble cytosine modification
DNA repair
regulation of translational initiation
regulation of translational elongation
oxidative RNA demethylation
positive chemotaxis
regulation of mitochondrial translation
positive regulation of gene expression, epigenetic
tRNA demethylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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