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Invitrogen
ACVR2B Monoclonal Antibody (A5H6)
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FIGURE: 1 / 1
ACVR2B Antibody (MA5-42556) in WB
Western blot analysis of ACVR2B on Hela cell lysates. Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. ACVR2B Monoclonal Antibody (Product # MA5-42556) at 1:500 was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Mouse IgG - HRP Secondary Antibody at 1:20,000 dilution was used for 1 hour at room temperature. Predicted band size: 58 kDa Observed band size: 50 kDa.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-42556
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
A5H6
Immunogen
Synthetic peptide within human ACVR2B aa 331-380.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Control: Hela cell lysates.
Subcellular Location: Cell membrane.
Target Information
ACVR2B is a type II member of the TGF-beta family of receptor ser/thr kinases and is involved in the activin and myostatin signaling pathway. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. To date, seven type I and five type II activin receptors have been cloned from mammals, including activin receptor IA, activin receptor IIA, activin receptor IB, and activin receptor IIB. In addition, two splice variants of activin receptor IIA and five splice variants of activin receptor IIB have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor, type IIB; activin A receptor, type IIBa; activin receptor IIB; activin receptor type IIB; Activine receptor 2b (transmembrane serine kinase); ACTR-IIB; ActRIIB type II activin receptor B; MGC116908; probable match to ACTIVIN RECEPTOR TYPE IIB PRECURSOR (ACTR-IIB); serine/threonine receptor kinase
Gene Aliases: 4930516B21Rik; ActR-IIB; actr2b; ACTRIIB; acvr2b; AI047905; HTX4; wu:fj97d11
UniProt ID: (Human) Q13705, (Mouse) P27040, (Rat) P38445
Entrez Gene ID: (Human) 93, (Mouse) 11481, (Rat) 25366, (Zebrafish) 30457
protein kinase activity
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
activin receptor activity, type II
activin-activated receptor activity
kinase activator activity
growth factor binding
activin binding
inhibin binding
transmembrane receptor protein kinase activity
nucleotide binding
kinase activity
transferase activity
metal ion binding
serine/threonine protein kinase receptor
negative regulation of transcription from RNA polymerase II promoter
lymphangiogenesis
blood vessel remodeling
regulation of transcription, DNA-templated
cellular iron ion homeostasis
signal transduction
transmembrane receptor protein serine/threonine kinase signaling pathway
pattern specification process
anterior/posterior pattern specification
negative regulation of ossification
positive regulation of bone mineralization
BMP signaling pathway
developmental process
activin receptor signaling pathway
positive regulation of activin receptor signaling pathway
positive regulation of osteoblast differentiation
lymphatic endothelial cell differentiation
artery development
venous blood vessel development
retina vasculature development in camera-type eye
trophoblast cell migration
cellular response to growth factor stimulus
negative regulation of cold-induced thermogenesis
negative regulation of adipose tissue development
skeletal system development
gastrulation with mouth forming second
kidney development
cell communication
determination of left/right symmetry
mesoderm development
heart development
response to glucose
post-embryonic development
regulation of signal transduction
signaling
insulin secretion
lung development
pancreas development
organ growth
odontogenesis of dentin-containing tooth
embryonic foregut morphogenesis
skeletal system morphogenesis
palate development
protein phosphorylation
response to activity
adrenal gland development
neural crest cell migration
phosphorylation
hindbrain development
cartilage development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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