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Invitrogen

TNFR1 Recombinant Rabbit Monoclonal Antibody (028)

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TNFR1 Recombinant Rabbit Monoclonal Antibody (028)

Product Details

MA5-43149

Applications
Tested Dilution
Publications

ELISA (ELISA)

1:5,000-1:10,000
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

028

Immunogen

Recombinant Mouse TNFR1/CD120a/TNFRSF1A protein (1-212).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2912285

Product Specific Information

Specificity: Mouse TNFR1/CD120a/TNFRSF1A

Target Information

TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD120a antigen; MGC19588; n-smase activation assoc. factor; p60; p62; p63; sCD120a; soluble CD120a; soluble TNFR1; sTNF RI; sTNFR I; sTNFR1; sTNFRI; TNF receptor alpha chain; TNF-alpha-R1; TNF-RI; TNFR; TNFR I; TNFR-I; tnfrsf1a; Tumor necrosis factor receptor; tumor necrosis factor receptor 1; tumor necrosis factor receptor type I; unnamed protein product

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Gene Aliases: CD120a; FPF; p55; p55-R; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNFalpha-R1; TNFAR; Tnfr-2; Tnfr1; TNFR60; TNFRI; TNFRp55

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UniProt ID: (Mouse) P25118

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Entrez Gene ID: (Mouse) 21937

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Function(s)
protease binding tumor necrosis factor-activated receptor activity protein binding signaling receptor activity identical protein binding tumor necrosis factor binding macromolecular complex binding
Process(es)
aortic valve development pulmonary valve development negative regulation of extracellular matrix constituent secretion prostaglandin metabolic process apoptotic process defense response inflammatory response signal transduction cell surface receptor signaling pathway JAK-STAT cascade extrinsic apoptotic signaling pathway via death domain receptors intrinsic apoptotic signaling pathway in response to DNA damage response to bacterium gene expression regulation of gene expression negative regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor-mediated signaling pathway cytokine-mediated signaling pathway negative regulation of interleukin-6 production positive regulation of tumor necrosis factor production tumor necrosis factor-mediated signaling pathway NIK/NF-kappaB signaling positive regulation of protein import into nucleus defense response to bacterium regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of neuron apoptotic process positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter astrocyte activation negative regulation of inflammatory response positive regulation of inflammatory response regulation of developmental process negative regulation of multicellular organismal process establishment of blood-brain barrier cellular response to lipopolysaccharide cellular response to mechanical stimulus protein localization to plasma membrane apoptotic signaling pathway positive regulation of execution phase of apoptosis positive regulation of apoptotic process involved in morphogenesis regulation of establishment of endothelial barrier
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