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Invitrogen
ERLIN2 Monoclonal Antibody (C2)
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FIGURE: 1 / 3
ERLIN2 Antibody (MA5-43834) in IHC (P)
Immunohistochemistry of ERLIN2 in paraffin-embedded human small intestine tissue. Samples were incubated in monoclonal ERLIN2 antibody (Product # MA5-43834) using a dilution of 40 µg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 2 µg/mL and DAB.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-43834
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, lambda
Class
Monoclonal
Type
Antibody
Clone
C2
Immunogen
Pro47-Asn339 (Accession O94905), with N-terminal His Tag
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
ERLIN2, also named as C8orf2 and SPFH2, is a component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1, 4, 5-trisphosphate receptors (IP3Rs) such as ITPR1. It promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. ERLIN2 is involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. The MW of ERLIN1/ERLIN2 complex is about 70 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endoplasmic reticulum lipid raft-associated protein 2; epididymis secretory sperm binding protein; HGNC:1356; MGC87072; spastic paraplegia 18 (autosomal dominant); SPFH domain family, member 2; stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2; unnamed protein product; UNQ2441
Gene Aliases: C8orf2; Erlin-2; NET32; SPFH2; SPG18; SPG18A; SPG18B
UniProt ID: (Human) O94905
Entrez Gene ID: (Human) 11160
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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