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Invitrogen
Procollagen I N-Peptide Monoclonal Antibody (H20)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-43884
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
H20
Immunogen
Recombinant PINP (Gln23-Pro161) expressed in E.coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Procollagen type I N-terminal propeptide (P1NP) is a specific marker of bone formation, reflecting the synthesis of type I collagen, which constitutes the major part of the bone matrix. P1NP is derived during the conversion of procollagen to collagen, produced by osteoblasts during bone formation. Its primary clinical application lies in the diagnosis and monitoring of metabolic bone diseases, particularly osteoporosis. In osteoporotic patients, P1NP levels can predict bone mineral density (BMD) responses to treatments like teriparatide and romosozumab. Low serum levels of P1NP are indicative of a high risk of BMD loss, providing a valuable tool for premenopausal women with systemic lupus erythematosus (SLE) and other conditions affecting bone health.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha 1 (I) chain propeptide; alpha-1 collagen type 1; alpha-1 collagen type I; alpha-1 type I collagen; alpha1(I) procollagen; COL1A1; collagen alpha 1 chain type I; collagen alpha-1(I) chain preproprotein; collagen Col1-ColIII-1; collagen Col1-ColIII-2; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; P1NP; pro-alpha-1 collagen type 1; Procollagen I N; type I proalpha 1; type I procollagen alpha 1 chain; unnamed protein product
Gene Aliases: CAFYD; EDSARTH1; EDSC; OI1; OI2; OI3; OI4
UniProt ID: (Human) P02452
Entrez Gene ID: (Human) 1277
skeletal system development
ossification
blood vessel development
osteoblast differentiation
response to nutrient
visual perception
sensory perception of sound
response to xenobiotic stimulus
response to mechanical stimulus
positive regulation of epithelial to mesenchymal transition
collagen fibril organization
positive regulation of cell migration
response to nutrient levels
response to estradiol
response to insulin
collagen biosynthetic process
protein localization to nucleus
tooth mineralization
response to hydrogen peroxide
response to peptide hormone
skin morphogenesis
cellular response to fibroblast growth factor stimulus
positive regulation of transcription, DNA-templated
animal organ development
response to steroid hormone
embryonic skeletal system development
system development
response to cAMP
response to hyperoxia
cellular response to mechanical stimulus
cellular response to retinoic acid
cellular response to vitamin E
cellular response to glucose stimulus
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to transforming growth factor beta stimulus
positive regulation of canonical Wnt signaling pathway
response to fluoride
cellular response to fluoride
cellular response to acetaldehyde
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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