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CD51/CD61 Monoclonal Antibody (23C6), PE

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CD51/CD61 Monoclonal Antibody (23C6), PE

Product Details

MA5-44118

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

10 µL/1x10^6 cells
-
Product Specifications

Species Reactivity

Chicken, Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

23C6

Immunogen

A cell suspension containing osteoclasts from osteoclastomas
3D Epitope / Immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra spectra

Form

Liquid

Concentration

0.08 mg/mL

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913050

Product Specific Information

This antibody recognizes an extracellular epitope on CD51/CD61 complex, that is expressed mainly on human osteoclasts, but also e.g. on placenta, or melanoma cell lines. The epitope is native and sensitive to fixation. In chicken this antibody can be used to selectively identify the thrombocytes.

Target Information

CD51 and CD61 molecules (alpha V and beta 3 integrins) form a complex. This complex binds vitronection at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

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Bioinformatics

Protein Aliases: antigen CD61; antigen identified by monoclonal antibody L230; glycoprotein IIIa precursor; integrin alpha-5 beta-3; integrin alphaVbeta3; Integrin beta; integrin beta 3; integrin beta chain, beta 3; integrin beta-3; integrin beta-3 subunit; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); plate glycoprotein IIIa (GPIIIa); platelet membrane glycoprotein IIIa; unnamed protein product; vitronectin alpha subunit precursor; vitronectin receptor alpha subunit; vitronectin receptor subunit alpha

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Gene Aliases: BDPLT16; BDPLT2; BDPLT24; CD51; CD61; FMAIT1; GP3A; GPIIIa; GT; GT2; IDNDC; integrin; MSK8; VNRA; VTNR

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UniProt ID: (Chicken) P26008, (Human) P06756, (Human) P05106

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Entrez Gene ID: (Chicken) 396420, (Human) 3685, (Chicken) 374209, (Human) 3690

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Function(s)
metal ion binding opsonin binding fibronectin binding protease binding protein kinase C binding receptor binding integrin binding protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding signaling receptor activity neuregulin binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding protein disulfide isomerase activity obsolete cell adhesion receptor activity platelet-derived growth factor receptor binding enzyme binding identical protein binding vascular endothelial growth factor receptor 2 binding cell adhesion molecule binding fibrinogen binding integrin
Process(es)
angiogenesis integrin-mediated signaling pathway cell adhesion mediated by integrin regulation of transforming growth factor beta activation vasculogenesis formation of primary germ layer cell adhesion cell-matrix adhesion positive regulation of cytosolic calcium ion concentration positive regulation of cell proliferation tissue development negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance cell migration positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading wound healing, spreading of epidermal cells endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway apoptotic cell clearance positive regulation of cell adhesion viral entry into host cell negative regulation of lipoprotein metabolic process regulation of phagocytosis negative chemotaxis positive regulation of small GTPase mediated signal transduction ERK1 and ERK2 cascade calcium ion transmembrane transport transforming growth factor beta production entry into host cell by a symbiont-containing vacuole extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion positive regulation of intracellular signal transduction negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway positive regulation of endothelial cell proliferation positive regulation of leukocyte migration embryo implantation blood coagulation regulation of G-protein coupled receptor protein signaling pathway positive regulation of endothelial cell migration positive regulation of gene expression positive regulation of fibroblast migration response to activity smooth muscle cell migration positive regulation of smooth muscle cell migration platelet activation positive regulation of vascular endothelial growth factor receptor signaling pathway regulation of protein localization regulation of actin cytoskeleton organization positive regulation of cell adhesion mediated by integrin cell-cell adhesion mediated by integrin tube development response to platelet-derived growth factor wound healing regulation of bone resorption positive regulation of angiogenesis positive regulation of bone resorption mesodermal cell differentiation positive regulation of smooth muscle cell proliferation regulation of developmental process regulation of transport regulation of multicellular organismal process regulation of release of sequestered calcium ion into cytosol regulation of serotonin uptake angiogenesis involved in wound healing positive regulation of ERK1 and ERK2 cascade platelet aggregation cellular response to mechanical stimulus cellular response to xenobiotic stimulus positive regulation of glomerular mesangial cell proliferation maintenance of postsynaptic specialization structure regulation of postsynaptic neurotransmitter receptor internalization regulation of postsynaptic neurotransmitter receptor diffusion trapping positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway positive regulation of vascular endothelial growth factor signaling pathway cellular response to insulin-like growth factor stimulus negative regulation of endothelial cell apoptotic process positive regulation of T cell migration
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