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Invitrogen
SOX10 Recombinant Rabbit Monoclonal Antibody (BLR080G)
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Product Details
MA5-44351
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR080G
Immunogen
Peptide representing a region between residue 416 and the C-terminus (residue 466) of human SOX10.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
50 µg/mL
Amount
5 µg
Purification
purified
Storage buffer
BBS, pH 8.2, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
Target Information
SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. It acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dominant megacolon, mouse, human homolog of; MGC15649; SOX10; SRY; SRY (sex determining region Y)-box 10; SRY-box 10; SRY-related HMG-box gene 10; unnamed protein product
Gene Aliases: DOM; PCWH; SOX-10; WS2E; WS4; WS4C
UniProt ID: (Human) P56693
Entrez Gene ID: (Human) 6663
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
morphogenesis of an epithelium
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
peripheral nervous system development
anatomical structure morphogenesis
negative regulation of Schwann cell proliferation
positive regulation of gene expression
oligodendrocyte development
positive regulation of gliogenesis
central nervous system myelination
positive regulation of myelination
developmental process
negative regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
enteric nervous system development
oligodendrocyte differentiation
stem cell differentiation
cellular response to progesterone stimulus
cellular response to xenobiotic stimulus
negative regulation of canonical Wnt signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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