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Invitrogen

FOXP1 Recombinant Rabbit Monoclonal Antibody (BLR134H)

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FOXP1 Recombinant Rabbit Monoclonal Antibody (BLR134H)

Product Details

MA5-44455

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1 µL/1x10^6 cells
-

Immunoprecipitation (IP)

20 µL/1 mg lysate
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

BLR134H

Immunogen

Peptide representing a region between residue 627 and the C-terminus (residue 677) of Human Forkhead box protein P1.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

30 µg/mL

Amount

3 µg

Purification

purified

Storage buffer

BBS, pH 7.8-8.6, with 0.1% BSA

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2926585

Product Specific Information

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

Target Information

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ23741; Fork head related protein like B; fork head-related protein like B; Forkhead box protein P1 (FOXP1); forkhead-related transcription factor 1; FOXP1; Foxp1b; Foxp1c; Glutamine rich factor 1; glutamine-rich factor 1; mac-1-regulated forkhead; MGC12942; MGC88572; MGC99551; unnamed protein product

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Gene Aliases: 12CC4; 3110052D19Rik; 4932443N09Rik; hFKH1B; HSPC215; MFH; QRF1

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UniProt ID: (Human) Q9H334, (Mouse) P58462

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Entrez Gene ID: (Human) 27086, (Mouse) 108655

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding sequence-specific DNA binding androgen receptor binding sequence-specific double-stranded DNA binding transcription regulatory region sequence-specific DNA binding transcription cofactor binding DNA binding chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter negative regulation of B cell apoptotic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus regulation of gene expression positive regulation of endothelial cell migration negative regulation of gene expression striatum development osteoclast differentiation forebrain development response to lipopolysaccharide regulation of interleukin-1 beta production regulation of interleukin-12 production regulation of tumor necrosis factor production positive regulation of interleukin-21 production response to testosterone osteoclast development macrophage activation monocyte activation endothelial cell activation regulation of monocyte differentiation negative regulation of transcription, DNA-templated animal organ development positive regulation of smooth muscle cell proliferation regulation of inflammatory response positive regulation of B cell receptor signaling pathway negative regulation of androgen receptor signaling pathway negative regulation of cell growth involved in cardiac muscle cell development T follicular helper cell differentiation cellular response to tumor necrosis factor regulation of defense response to bacterium regulation of macrophage colony-stimulating factor production positive regulation of hydrogen peroxide-mediated programmed cell death regulation of endothelial tube morphogenesis regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of mesenchymal cell proliferation pre-B cell differentiation positive regulation of immunoglobulin production heart development skeletal muscle tissue development motor neuron axon guidance ventral spinal cord development lung development immunoglobulin V(D)J recombination positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development positive regulation of epithelial cell proliferation cardiac muscle cell differentiation regulation of cardiac muscle cell proliferation regulation of androgen receptor signaling pathway lung secretory cell differentiation regulation of lung goblet cell differentiation negative regulation of lung goblet cell differentiation positive regulation of TORC1 signaling cellular response to ionomycin
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