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Invitrogen
STAT6 Recombinant Rabbit Monoclonal Antibody (BLR147J)
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Product Details
MA5-44481
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
BLR147J
Immunogen
Peptide representing a region between residue 600 and 650 of Human Signal Transducer and Activator of Transcription 6 (STAT6).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.3 mg/mL
Amount
30 µg
Purification
purified
Storage buffer
BBS, pH 7.8-8.6, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 12S1644; IL4 STAT; LITAF binding protein; Mutations: 16:OK; signal transducer and activator of transcription 6, interleukin-4 induced; STAT; STAT, interleukin4-induced; STAT-6; transcription factor IL-4 STAT; unnamed protein product
Gene Aliases: D12S1644; HIES6; IL-4-STAT; STAT6B; STAT6C
UniProt ID: (Human) P42226
Entrez Gene ID: (Human) 6778
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein phosphatase binding
identical protein binding
sequence-specific DNA binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
defense response
signal transduction
JAK-STAT cascade
gene expression
cytokine-mediated signaling pathway
interleukin-4-mediated signaling pathway
regulation of cell proliferation
response to peptide hormone
positive regulation of transcription from RNA polymerase II promoter
JAK-STAT cascade involved in growth hormone signaling pathway
positive regulation of cold-induced thermogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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