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Invitrogen

Adiponectin Recombinant Rabbit Monoclonal Antibody (JE65-49)

View all (34) Adiponectin antibodies

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Adiponectin Recombinant Rabbit Monoclonal Antibody (JE65-49)

Product Details

MA5-44744

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunocytochemistry (ICC/IF)

1:50
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JE65-49

Immunogen

Recombinant protein within mouse Adiponectin aa 1-247/247.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931202

Target Information

Adiponectin is a protein hormone secreted exclusively by adipocytes that regulates the metabolism of lipids and glucose. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity. Decreased levels of adiponectin are associated with obese individuals as well as insulin resistance and hyperinsulinemia (type 2 diabetes). In mice adiponectin has been shown to improve insulin signaling, thus ameliorating insulin resistance. Through activation of AMP kinase and PPAR-alpha, adiponectin can increase fatty acid transport, oxidation, and dissipation in skeletal muscle, leading to a reduction of intramyocellular lipid levels and thus improved insulin signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 30 kDa adipocyte complement-related protein; adipocyte complement related protein; adipocyte complement-related 30 kDa protein; adipocyte specific protein; adipocyte, C1Q and collagen domain containing; adipocyte, C1q and collagen domain-containing protein; adipocyte-specific protein AdipoQ; adiponectin d; ADPIOQ; circulating protein secreted from adipose tissue; circulating protein secreted from adipose tissue; adipoQ; apM1; adiponectin; GBP28; Acrp30; unnamed protein product

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Gene Aliases: 30kDa; Acdc; Acrp30; Ad; Adid; adipo; apM1; APN; GBP28

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UniProt ID: (Mouse) Q60994

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Entrez Gene ID: (Mouse) 11450

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Function(s)
receptor binding hormone activity extracellular matrix structural constituent protein binding sialic acid binding identical protein binding protein homodimerization activity protein serine/threonine kinase activator activity
Process(es)
glucose metabolic process fatty acid beta-oxidation response to bacterium response to glucose positive regulation of signal transduction gene expression negative regulation of platelet-derived growth factor receptor signaling pathway negative regulation of macrophage derived foam cell differentiation negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux regulation of glucose metabolic process fatty acid oxidation negative regulation of cell migration negative regulation of granulocyte differentiation negative regulation of tumor necrosis factor production positive regulation of interleukin-8 production cellular response to insulin stimulus positive regulation of myeloid cell apoptotic process adiponectin-activated signaling pathway negative regulation of heterotypic cell-cell adhesion low-density lipoprotein particle clearance response to tumor necrosis factor endocrine signaling glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity negative regulation of fat cell differentiation negative regulation of macrophage differentiation negative regulation of gluconeogenesis negative regulation of blood pressure positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of glucose import negative regulation of hormone secretion negative regulation of receptor-mediated endocytosis negative regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation negative regulation of phagocytosis negative regulation of synaptic transmission brown fat cell differentiation positive regulation of lipid catabolic process negative regulation of cholesterol import negative regulation of ERK1 and ERK2 cascade cellular response to cAMP cellular response to xenobiotic stimulus positive regulation of monocyte chemotactic protein-1 production cellular response to epinephrine stimulus protein localization to plasma membrane negative regulation of intracellular protein transport positive regulation of cold-induced thermogenesis negative regulation of cold-induced thermogenesis positive regulation of cAMP/PKA signal transduction negative regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell migration negative regulation of DNA biosynthetic process positive regulation of glycogen (starch) synthase activity positive regulation of renal albumin absorption negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of metanephric mesenchymal cell migration
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