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Invitrogen

Phospho-Tau-F (Thr231) Recombinant Rabbit Monoclonal Antibody (SC58-08)

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Phospho-Tau-F (Thr231) Recombinant Rabbit Monoclonal Antibody (SC58-08)

Product Details

MA5-45027

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunohistochemistry (Frozen) (IHC (F))

1:200-1:500
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

SC58-08

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Thr231 of human Tau-F.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2931481

Target Information

Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity. Tau is highly subject to a variety of post-translational modifications, including phosphorylation on serine and threonine residues, polyubiquitination (and subsequent proteasomal degradation) and glycation of specific Tau isoforms. Defects in the gene encoding Tau are associated with Alzheimers disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2N4R; G protein beta1/gamma2 subunit-interacting factor 1; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; protein phosphatase 1, regulatory subunit 103; Tau microtubule-associated protein; Tau-4; Tau-derived paired helical filament hexapeptide; unnamed protein product

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Gene Aliases: AI413597; AW045860; DDPAC; FTD1; FTDP-17; MAPT; MAPTL; MSTD; Mtapt; MTBT1; MTBT2; PPND; PPP1R103; pTau; RNPTAU; TAU; tau-40; Tau-PHF6

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UniProt ID: (Human) P10636, (Mouse) P10637

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Entrez Gene ID: (Human) 4137, (Rat) 29477, (Mouse) 17762

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Function(s)
DNA binding AT DNA binding double-stranded DNA binding single-stranded DNA binding RNA binding actin binding protein binding microtubule binding tubulin binding SH3 domain binding enzyme binding protein kinase binding protein binding, bridging apolipoprotein binding dynactin binding phosphatidylinositol binding identical protein binding sequence-specific DNA binding chaperone binding protein phosphatase 2A binding Hsp90 protein binding lipoprotein particle binding histone-dependent DNA binding microtubule lateral binding phosphatidylinositol bisphosphate binding protein domain specific binding protein complex binding
Process(es)
microtubule cytoskeleton organization microglial cell activation cellular response to DNA damage stimulus cell-cell signaling synapse assembly learning or memory memory response to lead ion regulation of autophagy negative regulation of gene expression negative regulation of mitochondrial membrane potential rRNA metabolic process axonal transport of mitochondrion central nervous system neuron development regulation of microtubule polymerization or depolymerization regulation of microtubule polymerization positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development positive regulation of superoxide anion generation regulation of chromosome organization stress granule assembly cellular response to heat cellular response to reactive oxygen species positive regulation of axon extension microtubule polymerization astrocyte activation regulation of synaptic plasticity intracellular distribution of mitochondria generation of neurons synapse organization regulation of calcium-mediated signaling protein polymerization protein homooligomerization axon development regulation of microtubule cytoskeleton organization plus-end-directed organelle transport along microtubule regulation of mitochondrial fission negative regulation of mitochondrial fission fibril organization axonal transport regulation of cellular response to heat regulation of long term synaptic depression positive regulation of protein localization to synapse neurofibrillary tangle assembly negative regulation of establishment of protein localization to mitochondrion positive regulation of cellular protein localization negative regulation of tubulin deacetylation amyloid fibril formation cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus neuron migration apoptotic process microtubule-based process axonogenesis brain development female pregnancy response to nutrient adult walking behavior axo-dendritic transport intrinsic apoptotic signaling pathway in response to oxidative stress response to organic substance neuron differentiation negative regulation of intracellular transport mitochondrion transport along microtubule axon extension regulation of microtubule-based movement
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