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Invitrogen

Aurora A/B Monoclonal Antibody (3H1)

View all (2) Aurora A/B antibodies

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Aurora A/B Monoclonal Antibody (3H1)

Product Details

MA5-47320

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (IHC)

1:500-1:1,000
-

Immunocytochemistry (ICC/IF)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

3H1

Immunogen

Full length recombinant human Aurora A protein expressed in and purified from E. coli.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

500 µg

Purification

Protein A/G

Storage buffer

PBS with 50% glycerol

Contains

5mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2942302

Target Information

The Aurora gene, a serine-threonine kinase, orginally discovered in Drosophila, has been found to be responsible for a chromosomal segregation defect. The mammalian homologues of Drosophila Aurora have been termed ARK1 (Aurora-related kinase 1) and ARK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIM-1; ARK-2; aurora 1; aurora 2; aurora A; aurora B; aurora family kinase 1; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and IPL1-like midbody-associated protein 1; aurora- and Ipl1-like midbody-associated protein 1 homolog; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; aurora/IPL1-related kinase 2; breast tumor-amplified kinase; IAK1; ipl1- and aurora-related kinase 1; protein kinase; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine-protein kinase 12; serine/threonine-protein kinase 15; serine/threonine-protein kinase 5; serine/threonine-protein kinase 6; serine/threonine-protein kinase aurora-A; serine/threonine-protein kinase aurora-B; serine/threonine-protein kinase Ayk1; STK6; aurora-A; IPL1-related kinase; AIK; BTAK; STK15; unnamed protein product

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Gene Aliases: AIK; AIK2; AIM-1; AIM1; AIRK1; AIRK2; ARK-1; ARK-2; ARK1; ARK2; AURA; AurB; aurkb-sv1; aurkb-sv2; Aurora-A; Ayk1; BTAK; IAK; IAK1; IPL1; PPP1R47; PPP1R48; STK-1; STK12; STK15; STK5; STK6; STK7

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UniProt ID: (Human) O14965, (Human) Q96GD4, (Mouse) P97477, (Rat) O55099, (Mouse) O70126

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Entrez Gene ID: (Human) 6790, (Human) 9212, (Rat) 261730, (Mouse) 20878, (Rat) 114592, (Mouse) 20877

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding protein kinase binding protein heterodimerization activity protein serine kinase activity molecular function activator activity kinase binding histone H1-4S27 kinase activity ubiquitin protein ligase binding histone kinase activity (H3-S10 specific) histone kinase activity (H3-S28 specific)
Process(es)
meiotic spindle organization microtubule cytoskeleton organization mitotic cell cycle chromatin remodeling protein phosphorylation spindle organization mitotic spindle organization spindle assembly involved in female meiosis I centrosome cycle mitotic centrosome separation response to wounding anterior/posterior axis specification negative regulation of gene expression peptidyl-serine phosphorylation regulation of protein stability response to estradiol positive regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of cytokinesis negative regulation of apoptotic process positive regulation of translation positive regulation of mitotic cell cycle meiotic cell cycle centrosome localization cilium disassembly protein localization to centrosome positive regulation of mitochondrial fission liver regeneration positive regulation of oocyte maturation positive regulation of meiotic cell cycle process involved in oocyte maturation neuron projection extension negative regulation of transcription from RNA polymerase II promoter negative regulation of B cell apoptotic process positive regulation of microtubule depolymerization positive regulation of telomere maintenance negative regulation of cytokinesis positive regulation of cytokinesis protein localization to kinetochore cellular response to UV cleavage furrow formation post-translational protein modification cell cycle G2/M phase transition mitotic cytokinesis checkpoint negative regulation of innate immune response mitotic spindle midzone assembly midbody abscission positive regulation of mitotic sister chromatid segregation negative regulation of protein localization to chromatin repair of mitotic kinetochore microtubule attachment defect negative regulation of cGAS/STING signaling pathway positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore mitotic sister chromatid biorientation mitotic cytokinesis regulation of microtubule-based process regulation of chromosome segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle spindle assembly checkpoint mitotic spindle assembly regulation of signal transduction by p53 class mediator positive regulation of mitotic sister chromatid separation positive regulation of attachment of mitotic spindle microtubules to kinetochore positive regulation of mitotic cytokinesis G2/M transition of mitotic cell cycle regulation of G2/M transition of mitotic cell cycle negative regulation of protein binding positive regulation of mitotic nuclear division regulation of centrosome cycle protein autophosphorylation positive regulation of protein phosphorylation attachment of mitotic spindle microtubules to kinetochore cGAS/STING signaling pathway
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