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Invitrogen
TDP-43 Monoclonal Antibody (3H8)
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FIGURE: 1 / 2
TDP-43 Antibody (MA5-47322) in IHC (PFA)
Immunohistochemistry analysis of TDP-43 in rat hippocampus section. Samples were stained with TDP-43 monoclonal antibody (Product # MA5-47420) using a dilution of 1:2,000 (red). Costained with chickenpAb to GFAP dilution 1:5,000 in green. The blue is DAPI staining of nuclear DNA. Following transcardial perfusion of rat with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45 μM, and free-float... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-47322
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Horse,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3H8
Immunogen
Full length recombinant human TDP43 expressed in and purified from E. coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
500 µg
Purification
Protein G
Storage buffer
PBS with 50% glycerol
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: OTTHUMP00000002171; OTTHUMP00000002173; RP4-635E18.2; TAR DNA-binding protein 43-like protein; TAR DNA-binding protein-43; TAR-binding protein; TARDBP; TARDBP alternative transcript S6; TARDBP alternative transcript S7; TARDBP alternative transcript S8; TARDBP alternative transcript S9; unnamed protein product
Gene Aliases: 1190002A23Rik; ALS10; TDP-43; Tdp43
UniProt ID: (Human) Q13148, (Mouse) Q921F2
Entrez Gene ID: (Bovine) 540632, (Pig) 100739753, (Human) 23435, (Horse) 100051482, (Rat) 298648, (Mouse) 230908
negative regulation of protein phosphorylation
RNA splicing
gene expression
regulation of gene expression
negative regulation of gene expression
regulation of protein stability
positive regulation of insulin secretion
response to endoplasmic reticulum stress
positive regulation of protein import into nucleus
regulation of circadian rhythm
regulation of apoptotic process
negative regulation by host of viral transcription
regulation of cell cycle
3'-UTR-mediated mRNA destabilization
3'-UTR-mediated mRNA stabilization
nuclear inner membrane organization
amyloid fibril formation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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